B6N.Cg-Mapkapk2tm1c(EUCOMM)Hmgu/Biat

Status

Available to order

EMMA IDEM:11549
International strain nameB6N.Cg-Mapkapk2tm1c(EUCOMM)Hmgu/Biat
Alternative nameC57BL/6N-Mapkapk2/Biat
Strain typeTargeted Mutant Strains : Conditional mutation
Allele/Transgene symbolMapkapk2tm1c(EUCOMM)Hmgu
Gene/Transgene symbolMapkapk2

Information from provider

ProviderAlexander Dohnal
Provider affiliationTumor Immunology, St. Anna Kinderkrebsforschung
Genetic informationMapkapk2tm1a(EUCOMM)Hmgu/H mice (EMMA strain EM:05658; EUCOMM clone HEPD0672_2_A02) were crossed with B6.129S4-Gt(ROSA)26Sortm1(FLP1)Dym/RainJ for flp recombinase-mediated deletion and production of conditional MK2 (or Mapkapk2) knock-out mice.
Phenotypic informationHomozygous:
none

Heterozygous:
none
References
  • The MAPK-Activated Kinase MK2 Attenuates Dendritic Cell-Mediated Th1 Differentiation and Autoimmune Encephalomyelitis.;Soukup Klara, Halfmann Angela, Le Bras Marie, Sahin Emine, Vittori Sarah, Poyer Fiona, Schuh Cornelia, Luger Romana, Niederreiter Birgit, Haider Thomas, Stoiber Dagmar, Blüml Stephan, Schabbauer Gernot, Kotlyarov Alexey, Gaestel Matthias, Felzmann Thomas, Dohnal Alexander M, ;2015;Journal of immunology (Baltimore, Md. : 1950);195;541-52; 26078274
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreUniversity of Veterinary Medicine, Vienna, Austria

Disease and phenotype information

IMPC phenotypes (gene matching)
  • abnormal bone structure / IMPC
  • increased circulating glucose level / IMPC
  • abnormal optic disk morphology / IMPC
  • abnormal clavicle morphology / IMPC
  • abnormal joint morphology / IMPC
  • increased large unstained cell number / IMPC
  • increased eosinophil cell number / IMPC
  • increased leukocyte cell number / IMPC
MGI phenotypes (gene matching)
  • altered response to myocardial infarction / MGI
  • impaired macrophage phagocytosis / MGI
  • no abnormal phenotype detected / MGI
  • increased susceptibility to bacterial infection / MGI
  • abnormal cytokine secretion / MGI
  • decreased myocardial infarction size / MGI
  • decreased cardiomyocyte apoptosis / MGI
  • abnormal macrophage derived foam cell morphology / MGI
  • increased spleen germinal center size / MGI
  • decreased circulating tumor necrosis factor level / MGI
  • decreased tumor necrosis factor secretion / MGI
  • decreased interferon-gamma secretion / MGI
  • increased interleukin-1 beta secretion / MGI
  • abnormal cytokine level / MGI
  • decreased susceptibility to endotoxin shock / MGI
  • increased susceptibility to bacterial infection induced morbidity/mortality / MGI

Literature references

  • The MAPK-Activated Kinase MK2 Attenuates Dendritic Cell-Mediated Th1 Differentiation and Autoimmune Encephalomyelitis.;Soukup Klara, Halfmann Angela, Le Bras Marie, Sahin Emine, Vittori Sarah, Poyer Fiona, Schuh Cornelia, Luger Romana, Niederreiter Birgit, Haider Thomas, Stoiber Dagmar, Blüml Stephan, Schabbauer Gernot, Kotlyarov Alexey, Gaestel Matthias, Felzmann Thomas, Dohnal Alexander M, ;2015;Journal of immunology (Baltimore, Md. : 1950);195;541-52; 26078274

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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