C57BL/6NCrl-Camk2b^{tm1b(EUCOMM)Hmgu}/Ieg

Status	Available to order
EMMA ID	EM:11526
International strain name	C57BL/6NCrl-Camk2b^{tm1b(EUCOMM)Hmgu}/Ieg
Alternative name	HEPD0667_4_A12
Strain type	Targeted Mutant Strains
Allele/Transgene symbol	Camk2b^{tm1b(EUCOMM)Hmgu}
Gene/Transgene symbol	Camk2b
Disclaimer	Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA: We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider	Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH)
Provider affiliation	Institute of Experimental Genetics, Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH)
Genetic information	This mouse line originates from EUCOMM ES clone HEPD0667_4_A12. For further details on the construction of this clone see the page at the IMPC portal. The critical exon(s) were flanked by loxP sites, and subsequent cre expression excised this critical sequence resulting in a knockout reporter allele. Click here for more information on EUCOMM final vectors.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	None available

Information from EMMA

Archiving centre	Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany
Animals used for archiving	heterozygous C57BL/6N

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

Autosomal dominant non-syndromic intellectual disability / Orphanet_178469

IMPC phenotypes (allele matching)

decreased anxiety-related response / IMPC
hyperactivity / IMPC
decreased vertical activity / IMPC
improved glucose tolerance / IMPC
decreased prepulse inhibition / IMPC
preweaning lethality, incomplete penetrance / IMPC

IMPC phenotypes (gene matching)

decreased vertical activity / IMPC
decreased prepulse inhibition / IMPC
preweaning lethality, incomplete penetrance / IMPC
decreased anxiety-related response / IMPC
hyperactivity / IMPC
improved glucose tolerance / IMPC

MGI phenotypes (gene matching)

decreased body size / MGI
decreased anxiety-related response / MGI
ataxia / MGI
impaired coordination / MGI
abnormal nest building behavior / MGI
abnormal object recognition memory / MGI
reduced long term potentiation / MGI
impaired balance / MGI
abnormal long term depression / MGI
abnormal long term potentiation / MGI
abnormal voluntary movement / MGI
nervous system phenotype / MGI
abnormal synaptic plasticity / MGI
homeostasis/metabolism phenotype / MGI
behavior/neurological phenotype / MGI
increased percent body fat/body weight / MGI
slow postnatal weight gain / MGI
impaired contextual conditioning behavior / MGI
decreased grip strength / MGI

Information on how we integrate external resources can be found here

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.

Search

INFRAFRONTIER^® and European Mouse Mutant Archive - EMMA^® are registered trademarks at the European Union Intellectual Property Office (EUIPO).