C57BL/6NTac-Bscl2em1(IMPC)H/H

Status

Available to order

EMMA IDEM:11506
Citation informationRRID:IMSR_EM:11506 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6NTac-Bscl2em1(IMPC)H/H
Alternative name
Strain typeEndonuclease-mediated
Allele/Transgene symbolBscl2em1(IMPC)H
Gene/Transgene symbolBscl2

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom
Animals used for archivingheterozygous C57BL/6NTac (USA) males, heterozygous C57BL/6NTac (USA) females

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • decreased locomotor activity / IMPC
  • increased circulating alanine transaminase level / IMPC
  • increased mean corpuscular hemoglobin / IMPC
  • increased monocyte cell number / IMPC
  • increased lean body mass / IMPC
  • increased fasting circulating glucose level / IMPC
  • increased circulating calcium level / IMPC
  • decreased erythrocyte cell number / IMPC
  • decreased respiratory quotient / IMPC
  • increased fluid intake / IMPC
  • decreased prepulse inhibition / IMPC
  • increased food intake / IMPC
  • decreased total body fat amount / IMPC
  • short tibia / IMPC
  • increased circulating alkaline phosphatase level / IMPC
  • increased circulating cholesterol level / IMPC
  • decreased body length / IMPC
  • decreased bone mineral content / IMPC
  • increased large unstained cell number / IMPC
  • increased circulating phosphate level / IMPC
  • increased cornea thickness / IMPC
  • decreased total retina thickness / IMPC
  • increased circulating HDL cholesterol level / IMPC
  • increased circulating aspartate transaminase level / IMPC
  • abnormal gait / IMPC
  • abnormal bone structure / IMPC
  • increased circulating total protein level / IMPC
  • increased mean corpuscular volume / IMPC
  • increased circulating serum albumin level / IMPC
  • increased neutrophil cell number / IMPC
  • improved glucose tolerance / IMPC
  • increased circulating glucose level / IMPC
MGI phenotypes (gene matching)
  • increased brown adipose tissue amount / MGI
  • enlarged heart / MGI
  • abnormal intestine morphology / MGI
  • abnormal small intestine morphology / MGI
  • enlarged liver / MGI
  • enlarged spleen / MGI
  • abnormal testis morphology / MGI
  • abnormal spermatogenesis / MGI
  • decreased body weight / MGI
  • decreased body size / MGI
  • polyphagia / MGI
  • increased circulating triglyceride level / MGI
  • increased circulating free fatty acid level / MGI
  • increased circulating HDL cholesterol level / MGI
  • hyperglycemia / MGI
  • decreased brown adipose tissue amount / MGI
  • abnormal white adipose tissue amount / MGI
  • decreased white adipose tissue amount / MGI
  • male infertility / MGI
  • abnormal spermiogenesis / MGI
  • abnormal glucose homeostasis / MGI
  • increased circulating insulin level / MGI
  • abnormal lipid homeostasis / MGI
  • hepatic steatosis / MGI
  • abnormal epididymis morphology / MGI
  • decreased circulating triglyceride level / MGI
  • asthenozoospermia / MGI
  • oligozoospermia / MGI
  • decreased circulating free fatty acid level / MGI
  • abnormal white adipose tissue morphology / MGI
  • increased liver weight / MGI
  • no phenotypic analysis / MGI
  • enlarged kidney / MGI
  • decreased circulating glycerol level / MGI
  • increased circulating glycerol level / MGI
  • increased lean body mass / MGI
  • abnormal phospholipid level / MGI
  • decreased energy expenditure / MGI
  • decreased adiponectin level / MGI
  • increased circulating cholesterol level / MGI
  • decreased oxygen consumption / MGI
  • impaired glucose tolerance / MGI
  • insulin resistance / MGI
  • abnormal fat pad morphology / MGI
  • liver/biliary system phenotype / MGI
  • homeostasis/metabolism phenotype / MGI
  • behavior/neurological phenotype / MGI
  • increased body temperature / MGI
  • increased circulating glucose level / MGI
  • decreased circulating glucose level / MGI
  • teratozoospermia / MGI
  • decreased circulating leptin level / MGI
  • abnormal white adipose tissue physiology / MGI
  • abnormal epididymal fat pad morphology / MGI
  • abnormal male germ cell morphology / MGI
  • abnormal spermatid morphology / MGI
  • enhanced lipolysis / MGI
  • decreased subcutaneous adipose tissue amount / MGI
  • abnormal sperm flagellum morphology / MGI
  • decreased carbon dioxide production / MGI
  • abnormal white fat cell morphology / MGI
  • decreased white fat cell number / MGI
  • decreased white fat cell size / MGI
  • abnormal sperm head morphology / MGI
  • decreased gonadal fat pad weight / MGI
  • decreased inguinal fat pad weight / MGI
  • decreased interscapular fat pad weight / MGI
  • decreased mesenteric fat pad weight / MGI
  • decreased renal fat pad weight / MGI
  • decreased retroperitoneal fat pad weight / MGI
  • increased liver triglyceride level / MGI
  • decreased total body fat amount / MGI
  • abnormal cellular respiration / MGI
  • abnormal aerobic respiration / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • preweaning lethality, incomplete penetrance / MGI
  • abnormal hypodermis fat layer morphology / MGI
  • abnormal adipose tissue development / MGI
  • abnormal fat cell differentiation / MGI
  • abnormal white fat cell differentation / MGI
  • lipodystrophy / MGI
  • increased food intake / MGI
  • abnormal lipid metabolism / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

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Practical information

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