B6.C(129)-Tg(CMV-cre)1Cgn/CgnCnrm

Status	Available to order
EMMA ID	EM:01149
Citation information	RRID:IMSR_EM:01149 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	B6.C(129)-Tg(CMV-cre)1Cgn/CgnCnrm
Alternative name	B6.129-Cre-Deleter
Strain type	Transgenic Strains
Allele/Transgene symbol	Tg(CMV-cre)1Cgn
Gene/Transgene symbol	Tg(CMV-cre)1Cgn

Information from provider

Provider	Klaus Rajewsky
Provider affiliation	CBR Institute for Biomedical Research, Immune Disease Institute
Genetic information	Original transgene construct for the expression of cre recombinase under the control of a human cytomegalovirus (CMV) promoter, active in most mouse cells and tissues.
Phenotypic information	Original cre recombinase-expressing transgenic mouse strain for the ubiquitous deletion in vivo ("deleter strain") of loxP-flanked gene segments.
Breeding history	Backcrossed to 129 (more than 5 generations) then backcrossed to C57BL/6 (7-8 generations)
References	A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells.;Schwenk F, Baron U, Rajewsky K, ;1995;Nucleic acids research;23;5080-1; 8559668

Information from EMMA

Archiving centre	CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy
Animals used for archiving	heterozygous C57BL/6 males, wild-type C57BL/6 females
Stage of embryos	8-cell

Literature references

A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells.;Schwenk F, Baron U, Rajewsky K, ;1995;Nucleic acids research;23;5080-1; 8559668
Liver-derived ketone bodies are necessary for food anticipation.;Chavan Rohit, Feillet Céline, Costa Sara S Fonseca, Delorme James E, Okabe Takashi, Ripperger Jürgen A, Albrecht Urs, ;2016;Nature communications;7;10580; 26838474
PER2 mediates CREB-dependent light induction of the clock gene Per1.;Brenna Andrea, Ripperger Jürgen A, Saro Gabriella, Glauser Dominique A, Yang Zhihong, Albrecht Urs, ;2021;Scientific reports;11;21766; 34741086

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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