IMPC phenotypes (gene matching)
B6.129P2-Cd19tm1(cre)Cgn/CgnCnrm
| Status | Available to order |
| EMMA ID | EM:01147 |
| Citation information | RRID:IMSR_EM:01147 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129P2-Cd19tm1(cre)Cgn/CgnCnrm |
| Alternative name | CD19-Cre |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Cd19tm1(cre)Cgn |
| Gene/Transgene symbol | Cd19 |
Information from provider
| Provider | Klaus Rajewsky |
| Provider affiliation | CBR Institute for Biomedical Research, Immune Disease Institute |
| Genetic information | Original targeted mutation for the specific expression of cre recombinase in B-lymphocytes throughout development and differentiation. In-frame insertion of a cre recombinase gene into the first coding exon of the Cd19 gene, followed by an frt-flanked neomycin cassette. The endogenous Cd19 promoter drives the cre recombinase expression. |
| Phenotypic information | Original strain for cre recombinase expression throughout B-lymphocyte development and differentiation. Heterozygous mice are normal and can be crossed to mice carrying floxed gene targets for their specific, in vivo deletion in B-lymphocytes. |
| Breeding history | Backcrossed to C57BL/6 (6-7 generations). |
| References |
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Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Common variable immunodeficiency / Orphanet_1572
MGI phenotypes (gene matching)
- decreased neutrophil cell number / MGI
- demyelination / MGI
- thick dermal layer / MGI
- abnormal humoral immune response / MGI
- decreased IgM level / MGI
- decreased IgA level / MGI
- abnormal B cell differentiation / MGI
- no abnormal phenotype detected / MGI
- abnormal B cell physiology / MGI
- abnormal immunoglobulin level / MGI
- decreased IgE level / MGI
- decreased anti-nuclear antigen antibody level / MGI
- decreased anti-double stranded DNA antibody level / MGI
- increased susceptibility to experimental autoimmune encephalomyelitis / MGI
- decreased B-1 B cell number / MGI
- decreased B cell number / MGI
- decreased B cell proliferation / MGI
- increased susceptibility to injury / MGI
- increased CD8-positive, alpha-beta T cell number / MGI
- absent spleen germinal center / MGI
- decreased IgG1 level / MGI
- decreased IgG2a level / MGI
- decreased IgG2b level / MGI
- decreased IgG3 level / MGI
- decreased circulating tumor necrosis factor level / MGI
- decreased tumor necrosis factor secretion / MGI
- increased interferon-gamma secretion / MGI
- decreased circulating interferon-gamma level / MGI
- decreased circulating interleukin-10 level / MGI
- decreased circulating interleukin-6 level / MGI
- decreased circulating interleukin-4 level / MGI
- decreased interleukin-10 secretion / MGI
- decreased physiological sensitivity to xenobiotic / MGI
- increased sensitivity to induced morbidity/mortality / MGI
- skin fibrosis / MGI
Literature references
- B lymphocyte-specific, Cre-mediated mutagenesis in mice.;Rickert R C, Roes J, Rajewsky K, ;1997;Nucleic acids research;25;1317-8; 9092650