MGI phenotypes (allele matching)
- enlarged spleen / MGI
B6.129P2-Lyz2tm1(cre)Ifo/CgnCnrm
| Status | Available to order |
| EMMA ID | EM:01145 |
| Citation information | RRID:IMSR_EM:01145 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129P2-Lyz2tm1(cre)Ifo/CgnCnrm |
| Alternative name | Lyzs-Cre |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Lyz2tm1(cre)Ifo |
| Gene/Transgene symbol | Lyz2 |
Information from provider
| Provider | Klaus Rajewsky |
| Provider affiliation | CBR Institute for Biomedical Research, Immune Disease Institute |
| Genetic information | This strain expresses the cre recombinase protein in myeloid cells due to targeted insertion of the cre cDNA into their endogenous M lysozyme (Lyz2) locus. An NLS-cre gene was inserted into the endogenous ATG start site of the endogenous Lyz2 gene. An frt-flanked neomycin cassette was removed in ES cells via Flp-mediated recombination prior to production of chimeric mice. |
| Phenotypic information | This strain allows in vivo conditional gene targeting in macrophages and granulocytes. |
| Breeding history | Backcrossed to C57BL/6 (6-7 generations) |
| References |
|
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
MGI phenotypes (gene matching)
- ruffled hair / MGI
- abnormal liver morphology / MGI
- enlarged spleen / MGI
- lung hemorrhage / MGI
- hypoactivity / MGI
- hunched posture / MGI
- increased inflammatory response / MGI
- respiratory failure / MGI
- premature death / MGI
- abnormal pulmonary alveolus morphology / MGI
- abnormal lung interstitium morphology / MGI
- increased lactate dehydrogenase level / MGI
- no phenotypic analysis / MGI
- abnormal surfactant secretion / MGI
- abnormal enzyme/coenzyme level / MGI
- abnormal alveolar macrophage morphology / MGI
- absent type II pneumocytes / MGI
Literature references
- Conditional gene targeting in macrophages and granulocytes using LysMcre mice.;Clausen B E, Burkhardt C, Reith W, Renkawitz R, Förster I, ;1999;Transgenic research;8;265-77; 10621974
- Myeloid Heme Oxygenase-1 Regulates the Acute Inflammatory Response to Zymosan in the Mouse Air Pouch.;Brines Rita, Catalán Laura, Alcaraz Maria José, Ferrándiz Maria Luisa, ;2018;Oxidative medicine and cellular longevity;2018;5053091; 29599896