C57BL/6NTac-Hcn1^em1(IMPC)H/H

Status	Available to order
EMMA ID	EM:11420
Citation information	RRID:IMSR_EM:11420 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	C57BL/6NTac-Hcn1^em1(IMPC)H/H
Alternative name
Strain type	Endonuclease-mediated
Allele/Transgene symbol	Hcn1^em1(IMPC)H
Gene/Transgene symbol	Hcn1

Information from provider

Provider	MRC, Medical Research Council
Provider affiliation	Mary Lyon Centre at MRC Harwell
Genetic information	This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	None available

Information from EMMA

Archiving centre	Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom
Animals used for archiving	heterozygous C57BL/6NTac (USA) males

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

Undetermined early-onset epileptic encephalopathy / Orphanet_442835
Generalized epilepsy with febrile seizures-plus / Orphanet_36387

IMPC phenotypes (allele matching)

tremors / IMPC
abnormal locomotor behavior / IMPC
decreased locomotor activity / IMPC
abnormal gait / IMPC
decreased exploration in new environment / IMPC
increased heart weight / IMPC
abnormal auditory brainstem response / IMPC
decreased heart rate / IMPC
prolonged RR interval / IMPC

IMPC phenotypes (gene matching)

abnormal gait / IMPC
decreased heart rate / IMPC
decreased locomotor activity / IMPC
decreased exploration in new environment / IMPC
prolonged RR interval / IMPC
increased heart weight / IMPC
abnormal auditory brainstem response / IMPC
tremors / IMPC
abnormal locomotor behavior / IMPC

MGI phenotypes (gene matching)

abnormal spatial learning / MGI
abnormal pain threshold / MGI
abnormal learning/memory/conditioning / MGI
no abnormal phenotype detected / MGI
abnormal nervous system electrophysiology / MGI
increased thigmotaxis / MGI
abnormal motor learning / MGI
abnormal eye blink conditioning behavior / MGI
no phenotypic analysis / MGI
abnormal depression-related behavior / MGI
decreased cardiac output / MGI
increased heart rate variability / MGI
abnormal heartbeat / MGI
abnormal myocardial fiber physiology / MGI
behavior/neurological phenotype / MGI
abnormal action potential / MGI
abnormal sinoatrial node conduction / MGI
abnormal RR interval / MGI
sinoatrial block / MGI
sinus bradycardia / MGI

Information on how we integrate external resources can be found here

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*
Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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