MGI phenotypes (allele matching)
- decreased rhombomere 3 size / MGI
STOCK Egr2tm3Pch Egr3tm1Jmi Tg(CD2-icre)4Kio/H
| Status | Available to order |
| EMMA ID | EM:11389 |
| International strain name | STOCK Egr2tm3Pch Egr3tm1Jmi Tg(CD2-icre)4Kio/H |
| Alternative name | CD2-Egr2/3 KO mouse |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(CD2-icre)4Kio, Egr2tm3Pch, Egr3tm1Jmi |
| Gene/Transgene symbol | Tg(CD2-icre)4Kio, Egr2, Egr3 |
Information from provider
| Provider | Suling Li |
| Provider affiliation | Life Science, Brunel University |
| Genetic information | Egr3-/- and CD2-specific Egr2-/- (CD2-Egr2-/- Egr3-/-) mice were generated by interbreeding Egr3-/- (Tourtellotte and Milbrandt, 1998) and CD2-specific Egr2 -/- mice (Zhu et al., 2008) on the C57BL/6 background. |
| Phenotypic information | Homozygous:The KO mice with deletion of both transcription factors Egr2 and Egr3 in lymphocytes resulted in a lethal autoimmune syndrome with excessive serum proinflammatory cytokines but also impaired antigen receptor-induced proliferation of B and T cells.Heterozygous:Inflammation similar as homozygous but less severe. |
| Breeding history | C57BL/6 with 129/SvJ |
| References | None available |
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Dejerine-Sottas syndrome / Orphanet_64748
- Charcot-Marie-Tooth disease type 1D / Orphanet_101084
- Charcot-Marie-Tooth disease type 4E / Orphanet_99951
MGI phenotypes (gene matching)
- abnormal mandible morphology / MGI
- tremors / MGI
- weakness / MGI
- paralysis / MGI
- hindlimb paralysis / MGI
- abnormal myelination / MGI
- abnormal rhombomere morphology / MGI
- abnormal motor neuron morphology / MGI
- abnormal spinal cord morphology / MGI
- abnormal neuromuscular synapse morphology / MGI
- abnormal cranial nerve morphology / MGI
- abnormal trigeminal nerve morphology / MGI
- abnormal abducens nerve morphology / MGI
- abnormal facial nerve morphology / MGI
- abnormal glossopharyngeal nerve morphology / MGI
- abnormal vagus nerve morphology / MGI
- abnormal cranial ganglia morphology / MGI
- abnormal geniculate ganglion morphology / MGI
- abnormal trigeminal ganglion morphology / MGI
- abnormal glossopharyngeal ganglion morphology / MGI
- abnormal vagus ganglion morphology / MGI
- abnormal Schwann cell morphology / MGI
- decreased body weight / MGI
- weight loss / MGI
- decreased body size / MGI
- delayed eyelid opening / MGI
- hypoactivity / MGI
- impaired coordination / MGI
- abnormal gait / MGI
- impaired limb coordination / MGI
- postnatal growth retardation / MGI
- respiratory distress / MGI
- abnormal motor capabilities/coordination/movement / MGI
- abnormal skeleton development / MGI
- abnormal neural tube morphology / MGI
- abnormal sciatic nerve morphology / MGI
- abnormal aortic valve morphology / MGI
- abnormal somatic nervous system morphology / MGI
- short tibia / MGI
- abnormal cochlear ganglion morphology / MGI
- abnormal bone mineralization / MGI
- no phenotypic analysis / MGI
- abnormal long bone epiphyseal plate morphology / MGI
- short femur / MGI
- decreased width of hypertrophic chondrocyte zone / MGI
- abnormal long bone morphology / MGI
- abnormal bone structure / MGI
- short radius / MGI
- fusion of glossopharyngeal and vagus nerve / MGI
- decreased length of long bones / MGI
- increased pulmonary respiratory rate / MGI
- abnormal neuronal migration / MGI
- abnormal hindbrain development / MGI
- decreased diameter of long bones / MGI
- decreased diameter of femur / MGI
- decreased diameter of radius / MGI
- decreased diameter of tibia / MGI
- decreased nerve conduction velocity / MGI
- enlarged aortic valve / MGI
- thick aortic valve cusps / MGI
- thick pulmonary valve cusps / MGI
- integument phenotype / MGI
- lethality at weaning, complete penetrance / MGI
- postnatal lethality, complete penetrance / MGI
- postnatal lethality, incomplete penetrance / MGI
- neonatal lethality, incomplete penetrance / MGI
- increased Schwann cell proliferation / MGI
- decreased rhombomere 3 size / MGI
- absent rhombomere 3 / MGI
- decreased rhombomere 5 size / MGI
- absent rhombomere 5 / MGI
- decreased rhombomere 6 size / MGI