AnxA1tg
| Status | Available to order |
| EMMA ID | EM:11385 |
| Citation information | RRID:IMSR_EM:11385 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | AnxA1tg |
| Alternative name | AnxA1tg |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Unknown at present |
| Gene/Transgene symbol | Tg(CD2-Anxa1) |
Information from provider
| Provider | Fulvio D'Acquisto |
| Provider affiliation | Centre for Biochemical Pharmacology, William Harvey Research Institute, Queen Mary University of London |
| Genetic information | Annexin-a1 transgenic mice |
| Phenotypic information | Homozygous:Transgenic mice overexpressing Annexin-A1 in T cells. T cells from these mice show a lower threshold of TCR activation in vitro. They develop more severe signs of autoimmunity in the experimental autoimmune encephalomyelitis (EAE) and pristane-induced lupus. They also present a basal higher level of anxiety-like behavior.Heterozygous:Transgenic mice overexpressing Annexin-A1 in T cells. T cells from these mice show a lower threshold of TCR activation in vitro. They develop more severe signs of autoimmunity in the EAE and pristane-induced lupus. They also present a basal higher level of anxiety-like behavior. |
| Breeding history | Mice have been first backcrossed on C57BL/6 background and then intercrossed to generate AnxA1tg+/+ |
| References | None available |
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | yes |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |