AnxA1tg

Status

Available to order

EMMA IDEM:11385
International strain nameAnxA1tg
Alternative nameAnxA1tg
Strain typeTransgenic Strains
Allele/Transgene symbolUnknown at present
Gene/Transgene symbolTg(CD2-Anxa1)

Information from provider

ProviderFulvio D'Acquisto
Provider affiliationCentre for Biochemical Pharmacology, William Harvey Research Institute, Queen Mary University of London
Genetic informationAnnexin-a1 transgenic mice
Phenotypic informationHomozygous:
Transgenic mice overexpressing Annexin-A1 in T cells. T cells from these mice show a lower threshold of TCR activation in vitro. They develop more severe signs of autoimmunity in the experimental autoimmune encephalomyelitis (EAE) and pristane-induced lupus. They also present a basal higher level of anxiety-like behavior.

Heterozygous:
Transgenic mice overexpressing Annexin-A1 in T cells. T cells from these mice show a lower threshold of TCR activation in vitro. They develop more severe signs of autoimmunity in the EAE and pristane-induced lupus. They also present a basal higher level of anxiety-like behavior.
Breeding historyMice have been first backcrossed on C57BL/6 background and then intercrossed to generate AnxA1tg+/+
ReferencesNone available
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedyes

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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