IMPC phenotypes (allele matching)
C57BL/6NTac-Gckem1(IMPC)H/H
| Status | Available to order |
| EMMA ID | EM:11373 |
| International strain name | C57BL/6NTac-Gckem1(IMPC)H/H |
| Alternative name | |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Gckem1(IMPC)H |
| Gene/Transgene symbol | Gck |
Information from provider
| Provider | MRC, Medical Research Council |
| Provider affiliation | Mary Lyon Centre at MRC Harwell |
| Genetic information | This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
| Animals used for archiving | heterozygous C57BL/6NTacUSA, heterozygous C57BL/6NTacUSA |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Hyperinsulinism due to glucokinase deficiency / Orphanet_79299
- MODY / Orphanet_552
- Permanent neonatal diabetes mellitus / Orphanet_99885
IMPC phenotypes (gene matching)
MGI phenotypes (gene matching)
- abnormal circulating cholesterol level / MGI
- hypoglycemia / MGI
- increased body weight / MGI
- decreased body weight / MGI
- increased circulating triglyceride level / MGI
- increased circulating free fatty acid level / MGI
- hyperglycemia / MGI
- abnormal circulating insulin level / MGI
- postnatal growth retardation / MGI
- increased urine glucose level / MGI
- abnormal glucose homeostasis / MGI
- increased circulating insulin level / MGI
- postnatal lethality / MGI
- increased circulating ketone body level / MGI
- hepatic steatosis / MGI
- decreased circulating insulin level / MGI
- decreased insulin secretion / MGI
- abnormal pancreatic beta cell physiology / MGI
- abnormal insulin secretion / MGI
- abnormal pancreatic islet morphology / MGI
- abnormal pancreatic beta cell morphology / MGI
- impaired glucose tolerance / MGI
- insulin resistance / MGI
- homeostasis/metabolism phenotype / MGI
- endocrine/exocrine gland phenotype / MGI
- decreased glycogen level / MGI
- increased circulating glucose level / MGI
- decreased circulating glucose level / MGI
- increased glycosylated hemoglobin level / MGI
- decreased pancreatic beta cell mass / MGI
- small pancreatic islets / MGI
- mortality/aging / MGI
- postnatal lethality, complete penetrance / MGI
- embryonic lethality during organogenesis, incomplete penetrance / MGI
- decreased glucokinase activity / MGI