- decreased body weight / MGI
- abnormal placenta labyrinth morphology / MGI
- postnatal growth retardation / MGI
- fetal growth retardation / MGI
- abnormal placental labyrinth vasculature morphology / MGI
- decreased fetal weight / MGI
- preweaning lethality, incomplete penetrance / MGI
- abnormal syncytiotrophoblast morphology / MGI
DBA.129S2(Cg)-Synbtm1.2Ics/Orl
Status | Available to order |
EMMA ID | EM:11300 |
Citation information | RRID:IMSR_EM:11300 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
International strain name | DBA.129S2(Cg)-Synbtm1.2Ics/Orl |
Alternative name | DBA/2J Syncytin-B KO |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Synbtm1.2Ics |
Gene/Transgene symbol | Synb |
Information from provider
Provider | Thierry Heidmann |
Provider affiliation | Institut Gustave Roussy, UMR9196 CNRS |
Genetic information | Mice containing an excised copy of the Syncytin-B open reading frame. |
Phenotypic information | Homozygous:Homozygous null embryos display an impaired placentation, with late onset growth retardation and reduced neonate numbers.Heterozygous:no phenotypic alteration |
Breeding history | The original founder (B6.129/Sv) was backcrossed 10 times to DBA/2J. Then, four homozygous mutant siblings, obtained from two couples, were bred and the mutant strain was subsequently maintained in a homozygous state for more than 7 generations. |
References |
|
Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | not known |
Information from EMMA
Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Animals used for archiving | homozygous DBA/2 males |
Disease and phenotype information
MGI phenotypes (allele matching)
MGI phenotypes (gene matching)
- decreased body weight / MGI
- abnormal placenta labyrinth morphology / MGI
- postnatal growth retardation / MGI
- no phenotypic analysis / MGI
- fetal growth retardation / MGI
- abnormal placental labyrinth vasculature morphology / MGI
- decreased fetal weight / MGI
- preweaning lethality, incomplete penetrance / MGI
- abnormal syncytiotrophoblast morphology / MGI
Literature references
- Genetic Evidence That Captured Retroviral Envelope syncytins Contribute to Myoblast Fusion and Muscle Sexual Dimorphism in Mice.;Redelsperger François, Raddi Najat, Bacquin Agathe, Vernochet Cécile, Mariot Virginie, Gache Vincent, Blanchard-Gutton Nicolas, Charrin Stéphanie, Tiret Laurent, Dumonceaux Julie, Dupressoir Anne, Heidmann Thierry, ;2016;PLoS genetics;12;e1006289; 27589388
- Role of the captured retroviral envelope syncytin-B gene in the fusion of osteoclast and giant cell precursors and in bone resorption, analyzed ex vivo and in vivo in syncytin-B knockout mice.;Coudert Amélie E, Redelsperger François, Chabbi-Achengli Yasmine, Vernochet Cécile, Marty Caroline, Decrouy Xavier, Heidmann Thierry, de Vernejoul Marie-Christine, Dupressoir Anne, ;2019;Bone reports;11;100214; 31360740
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