C57BL/6N-Herc1em2(IMPC)Wtsi/WtsiOrl

Status

Available to order

EMMA IDEM:11277
International strain nameC57BL/6N-Herc1em2(IMPC)Wtsi/WtsiOrl
Alternative name
Strain typeEndonuclease-mediated
Allele/Transgene symbolHerc1em2(IMPC)Wtsi
Gene/Transgene symbolHerc1

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (allele matching)
IMPC phenotypes (gene matching)
  • impaired glucose tolerance / IMPC
  • decreased bone mineral content / IMPC
  • decreased lean body mass / IMPC
  • increased eosinophil cell number / IMPC
  • increased circulating alkaline phosphatase level / IMPC
  • increased Ly6C high monocyte number / IMPC
  • decreased bone mineral density / IMPC
  • increased Ly6C low monocyte number / IMPC
  • increased circulating insulin level / IMPC
  • increased monocyte cell number / IMPC
  • increased red blood cell distribution width / IMPC
  • abnormal lens morphology / IMPC
  • increased leukocyte cell number / IMPC
  • increased total body fat amount / IMPC
  • increased circulating chloride level / IMPC
  • increased mean platelet volume / IMPC
  • abnormal auditory brainstem response / IMPC
  • increased circulating sodium level / IMPC
  • abnormal retina morphology / IMPC
  • increased circulating amylase level / IMPC
  • decreased circulating glucose level / IMPC
  • increased fasting circulating glucose level / IMPC
  • male infertility / IMPC
  • cataract / IMPC
MGI phenotypes (gene matching)
  • abnormal cerebellar Purkinje cell layer / MGI
  • Purkinje cell degeneration / MGI
  • abnormal Purkinje cell morphology / MGI
  • decreased Purkinje cell number / MGI
  • decreased body height / MGI
  • impaired coordination / MGI
  • abnormal gait / MGI
  • limb grasping / MGI
  • decreased survivor rate / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.


Search
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).