MGI phenotypes (allele matching)
B6.129P2-Igh-Jtm1Cgn/CgnCnrm
| Status | Available to order |
| EMMA ID | EM:01127 |
| Citation information | RRID:IMSR_EM:01127 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129P2-Igh-Jtm1Cgn/CgnCnrm |
| Alternative name | Igh-JHT |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Igh-Jtm1Cgn |
| Gene/Transgene symbol | Igh-J |
Information from provider
| Provider | Klaus Rajewsky |
| Provider affiliation | CBR Institute for Biomedical Research, Immune Disease Institute |
| Genetic information | Deletion of JH1, 2, 3 and 4 elements including the DQ52 gene segment and the heavy chain enhancer. |
| Phenotypic information | B cell deficiency. Mice are immunosuppressed and show an impaired pathogen defense. |
| Breeding history | Backcrossed to C57BL/6 (more than 10 generations) |
| References |
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Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
MGI phenotypes (gene matching)
- spleen hypoplasia / MGI
- arrested B cell differentiation / MGI
- decreased IgG level / MGI
- decreased IgM level / MGI
- abnormal B cell differentiation / MGI
- no abnormal phenotype detected / MGI
- abnormal immunoglobulin level / MGI
- increased IgG level / MGI
- increased IgM level / MGI
- abnormal immune serum protein physiology / MGI
- increased pre-B cell number / MGI
- increased late pro-B cell number / MGI
- increased susceptibility to induced arthritis / MGI
- increased anti-double stranded DNA antibody level / MGI
- increased susceptibility to experimental autoimmune encephalomyelitis / MGI
- abnormal B cell morphology / MGI
- decreased spleen weight / MGI
- increased B-1 B cell number / MGI
- decreased B-1 B cell number / MGI
- decreased B cell number / MGI
- decreased T cell number / MGI
- immune system phenotype / MGI
- hematopoietic system phenotype / MGI
- abnormal T cell number / MGI
- absent B cells / MGI
- decreased B-1a cell number / MGI
- abnormal marginal zone B cell morphology / MGI
- increased marginal zone B cell number / MGI
- increased pro-B cell number / MGI
- decreased transitional stage B cell number / MGI
- decreased pre-B cell number / MGI
- increased mature B cell number / MGI
- decreased mature B cell number / MGI
- absent mature B cells / MGI
- increased immature B cell number / MGI
- decreased immature B cell number / MGI
- decreased IgG1 level / MGI
- decreased IgG2b level / MGI
- decreased IgG3 level / MGI
- abnormal B cell receptor editing / MGI
- decreased transitional stage T1 B cell number / MGI
- decreased transitional stage T2 B cell number / MGI
Literature references
- Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting.;Gu H, Zou Y R, Rajewsky K, ;1993;Cell;73;1155-64; 8513499