C57BL/6N-Cers1tm1a(EUCOMM)Hmgu/H

Status

Available to order

EMMA IDEM:11251
International strain nameC57BL/6N-Cers1tm1a(EUCOMM)Hmgu/H
Alternative nameHEPD0671_2_G02
Strain typeTargeted Mutant Strains
Allele/Transgene symbolCers1tm1a(EUCOMM)Hmgu
Gene/Transgene symbolCers1
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from EUCOMM ES clone HEPD0671_2_G02. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom
Animals used for archivingheterozygous C57BL/6NTacUSA, heterozygous C57BL/6NTacUSA
Breeding at archiving centreC57BL/6NTac

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • preweaning lethality, incomplete penetrance / IMPC
  • increased neutrophil cell number / IMPC
MGI phenotypes (gene matching)
  • tremors / MGI
  • small cerebellum / MGI
  • cerebellum vermis hypoplasia / MGI
  • Purkinje cell degeneration / MGI
  • decreased Purkinje cell number / MGI
  • decreased body weight / MGI
  • weight loss / MGI
  • decreased body size / MGI
  • abnormal anxiety-related response / MGI
  • ataxia / MGI
  • hyperactivity / MGI
  • hypoactivity / MGI
  • impaired balance / MGI
  • abnormal lipid level / MGI
  • seizures / MGI
  • premature death / MGI
  • abnormal lipid homeostasis / MGI
  • decreased brain weight / MGI
  • gliosis / MGI
  • abnormal motor learning / MGI
  • increased neuron apoptosis / MGI
  • neuron degeneration / MGI
  • astrocytosis / MGI
  • abnormal response to novel object / MGI
  • abnormal spatial working memory / MGI
  • abnormal Purkinje cell dendrite morphology / MGI
  • lipofuscinosis / MGI
  • reduced cerebellar foliation / MGI
  • mortality/aging / MGI
  • cerebellum atrophy / MGI

Information on how we integrate external resources can be found here

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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