B6;129-Hsp90ab1Gt(pGT1.8geo)1Pgr/Cnrm

Status

Under development - register interest

EMMA IDEM:00112
Citation informationRRID:IMSR_EM:00112 

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International strain nameB6;129-Hsp90ab1Gt(pGT1.8geo)1Pgr/Cnrm
Alternative nameHSP90b-gt
Strain typeGene-trap
Allele/Transgene symbolHsp90ab1Gt(pGT1.8geo)1Pgr
Gene/Transgene symbolHsp90ab1

Information from provider

ProviderPeter Gruss
Provider affiliationMax Planck Inst. Biophysical Chemistry
Genetic informationInsertion of the pGT1.8 geo construct in exon 9 of the Hsp90ab1 (Hspcb) locus.
Phenotypic informationMutant embryos fail to form a placental labyrinth and die at E10.5.
References
  • Mice lacking HSP90beta fail to develop a placental labyrinth.;Voss A K, Thomas T, Gruss P, ;2000;Development (Cambridge, England);127;1-11; 10654595

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

MGI phenotypes (allele matching)
  • abnormal placenta labyrinth morphology / MGI
  • abnormal placenta vasculature / MGI
  • absent heartbeat / MGI
  • abnormal trophoblast layer morphology / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI
  • embryo tissue necrosis / MGI
MGI phenotypes (gene matching)
  • abnormal placenta labyrinth morphology / MGI
  • abnormal placenta vasculature / MGI
  • absent heartbeat / MGI
  • abnormal trophoblast layer morphology / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI
  • embryo tissue necrosis / MGI

Literature references

  • Mice lacking HSP90beta fail to develop a placental labyrinth.;Voss A K, Thomas T, Gruss P, ;2000;Development (Cambridge, England);127;1-11; 10654595

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Register interest

Availabilities

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  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

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Practical information

Example health report
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