MGI phenotypes (allele matching)
B6.129X1(Cg)-Esr1tm1.1Gust/Kctt
| Status | Available to order |
| EMMA ID | EM:11180 |
| International strain name | B6.129X1(Cg)-Esr1tm1.1Gust/Kctt |
| Alternative name | B6.129X1-Esr1tm1.1Gust. |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Esr1tm1.1Gust |
| Gene/Transgene symbol | Esr1 |
Information from provider
| Provider | Per Antonson |
| Provider affiliation | Department of Biosciences and Nutrition, Karolinska Institutet |
| Genetic information | Global knockout of Esr1. Floxed exon 3 (B6.129X1-Esr1tm1Gust; EMMA strain EM:11179) deleted by Cre expression in mice. |
| Phenotypic information | Homozygous:Infertility in male and female mice.Heterozygous:none |
| References |
|
| Homozygous fertile | no |
| Homozygous viable | yes |
| Homozygous matings required | yes |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Karolinska Institutet, Stockholm, Sweden |
| Animals used for archiving | heterozygous C57BL/6J |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Estrogen resistance syndrome / Orphanet_785
MGI phenotypes (gene matching)
- increased white adipose tissue amount / MGI
- increased bone mineral density / MGI
- decreased bone mineral density / MGI
- decreased compact bone thickness / MGI
- abnormal vertebrae morphology / MGI
- abnormal bone marrow cell number / MGI
- impaired fertilization / MGI
- cortical renal glomerulopathies / MGI
- abnormal mammary gland development / MGI
- abnormal branching of the mammary ductal tree / MGI
- decreased thymocyte number / MGI
- abnormal hypothalamus morphology / MGI
- abnormal uterus morphology / MGI
- uterus hypoplasia / MGI
- abnormal ovary morphology / MGI
- impaired ovarian folliculogenesis / MGI
- abnormal ovarian folliculogenesis / MGI
- abnormal ovarian follicle morphology / MGI
- absent mature ovarian follicles / MGI
- absent corpus luteum / MGI
- abnormal vagina morphology / MGI
- abnormal vagina epithelium morphology / MGI
- abnormal testis morphology / MGI
- seminiferous tubule degeneration / MGI
- abnormal spermatogenesis / MGI
- decreased body length / MGI
- increased body weight / MGI
- obese / MGI
- decreased body weight / MGI
- increased body size / MGI
- increased aggression towards mice / MGI
- increased aggression towards females / MGI
- abnormal social investigation / MGI
- abnormal mating receptivity / MGI
- reduced male mating frequency / MGI
- abnormal pup retrieval / MGI
- pup cannibalization / MGI
- abnormal maternal nurturing / MGI
- hyperactivity / MGI
- abnormal skeleton physiology / MGI
- abnormal osteoclast physiology / MGI
- increased circulating HDL cholesterol level / MGI
- abnormal vasodilation / MGI
- failure of embryo implantation / MGI
- increased circulating follicle stimulating hormone level / MGI
- increased circulating luteinizing hormone level / MGI
- thymus hypoplasia / MGI
- reduced male fertility / MGI
- infertility / MGI
- male infertility / MGI
- female infertility / MGI
- ovary cysts / MGI
- abnormal skeleton development / MGI
- abnormal definitive hematopoiesis / MGI
- abnormal kidney physiology / MGI
- abnormal B cell differentiation / MGI
- abnormal reproductive system morphology / MGI
- no abnormal phenotype detected / MGI
- abnormal innervation / MGI
- abnormal seminiferous tubule morphology / MGI
- abnormal B cell number / MGI
- abnormal immunoglobulin level / MGI
- increased vertical activity / MGI
- abnormal epididymis morphology / MGI
- small uterus / MGI
- asthenozoospermia / MGI
- oligozoospermia / MGI
- abnormal nociception after inflammation / MGI
- glomerulonephritis / MGI
- decreased vertical activity / MGI
- short tibia / MGI
- decreased circulating testosterone level / MGI
- increased circulating testosterone level / MGI
- decreased heart weight / MGI
- increased growth rate / MGI
- albuminuria / MGI
- abnormal bone mineralization / MGI
- increased urine protein level / MGI
- no phenotypic analysis / MGI
- abnormal long bone epiphyseal plate morphology / MGI
- abnormal cell migration / MGI
- short femur / MGI
- testicular atrophy / MGI
- decreased ovulation rate / MGI
- impaired granulosa cell differentiation / MGI
- abnormal uterus development / MGI
- abnormal response/metabolism to endogenous compounds / MGI
- abnormal male reproductive system physiology / MGI
- abnormal female reproductive system physiology / MGI
- abnormal thymus physiology / MGI
- abnormal bone structure / MGI
- decreased aggression towards males / MGI
- decreased aggression towards mice / MGI
- impaired passive avoidance behavior / MGI
- abnormal vascular endothelial cell physiology / MGI
- decreased bone mass / MGI
- short ulna / MGI
- altered response of heart to induced stress / MGI
- decreased length of long bones / MGI
- decreased circulating insulin-like growth factor I level / MGI
- abnormal efferent ductules of testis morphology / MGI
- increased anti-double stranded DNA antibody level / MGI
- abnormal class switch recombination / MGI
- ovary hemorrhage / MGI
- abnormal testis weight / MGI
- decreased testis weight / MGI
- abnormal vascular wound healing / MGI
- decreased energy expenditure / MGI
- abnormal endometrium morphology / MGI
- decreased male germ cell number / MGI
- increased uterus weight / MGI
- decreased uterus weight / MGI
- enlarged uterus / MGI
- abnormal epididymis epithelium morphology / MGI
- decreased thymus weight / MGI
- increased osteoclast cell number / MGI
- decreased osteoblast cell number / MGI
- decreased bone strength / MGI
- decreased B cell number / MGI
- increased double-positive T cell number / MGI
- decreased circulating prolactin level / MGI
- increased luteinizing hormone level / MGI
- increased circulating cholesterol level / MGI
- decreased circulating estradiol level / MGI
- increased circulating estradiol level / MGI
- decreased circulating progesterone level / MGI
- impaired glucose tolerance / MGI
- insulin resistance / MGI
- adipose tissue phenotype / MGI
- growth/size/body region phenotype / MGI
- cardiovascular system phenotype / MGI
- behavior/neurological phenotype / MGI
- reproductive system phenotype / MGI
- skeleton phenotype / MGI
- hematopoietic system phenotype / MGI
- abnormal circulating protein level / MGI
- hyporesponsive to tactile stimuli / MGI
- increased circulating glucose level / MGI
- teratozoospermia / MGI
- decreased lung weight / MGI
- abnormal pituitary gland physiology / MGI
- decreased aggression / MGI
- increased circulating leptin level / MGI
- decreased long bone epiphyseal plate size / MGI
- abnormal rete testis morphology / MGI
- dilated rete testis / MGI
- decreased CD4-positive, alpha beta T cell number / MGI
- decreased CD8-positive, alpha-beta T cell number / MGI
- increased plasma cell number / MGI
- decreased mature B cell number / MGI
- decreased immature B cell number / MGI
- decreased lactotroph cell number / MGI
- increased spleen germinal center number / MGI
- abnormal mesonephros morphology / MGI
- increased IgG3 level / MGI
- abnormal spleen physiology / MGI
- abnormal lymph node cell ratio / MGI
- anovulation / MGI
- abnormal physiological response to xenobiotic / MGI
- decreased physiological sensitivity to xenobiotic / MGI
- detached sperm flagellum / MGI
- vagina hypoplasia / MGI
- absent estrous cycle / MGI
- uterus cysts / MGI
- endometrium hyperplasia / MGI
- decreased endometrial gland number / MGI
- increased white fat cell size / MGI
- increased white fat cell number / MGI
- dilated efferent ductules of testis / MGI
- abnormal internal male genitalia morphology / MGI
- enlarged endometrial glands / MGI
- dilated seminiferous tubules / MGI
- abnormal bone marrow cell physiology / MGI
- increased gonadal fat pad weight / MGI
- increased epididymal fat pad weight / MGI
- increased inguinal fat pad weight / MGI
- increased mammary fat pad weight / MGI
- increased parametrial fat pad weight / MGI
- increased renal fat pad weight / MGI
- increased retroperitoneal fat pad weight / MGI
- abnormal secondary ovarian follicle morphology / MGI
- increased theca cell number / MGI
- ovarian follicular cyst / MGI
- abnormal superovulation / MGI
- abnormal uterus physiology / MGI
- decreased birth weight / MGI
- abnormal chondrocyte physiology / MGI
- spermatic granuloma / MGI
- failure of ejaculation / MGI
- increased total body fat amount / MGI
- decreased bone mineral content / MGI
- increased compact bone area / MGI
- decreased compact bone area / MGI
- decreased primordial ovarian follicle number / MGI
- renal glomerulus hypertrophy / MGI
- expanded mesangial matrix / MGI
- abnormal seminiferous tubule epithelium morphology / MGI
- abnormal cremaster muscle morphology / MGI
- abnormal volumetric bone mineral density / MGI
- increased volumetric bone mineral density / MGI
- decreased volumetric bone mineral density / MGI
- decreased areal bone mineral density / MGI
- decreased bone ossification / MGI
- decreased bone mineralization / MGI
- renal glomerular immunoglobulin deposits / MGI
Literature references
- Generation of ERα-floxed and knockout mice using the Cre/LoxP system.;Antonson P, Omoto Y, Humire P, Gustafsson J-Å, ;2012;Biochemical and biophysical research communications;424;710-6; 22800760
- Estrogen Receptor-α Knockout Mice.;Antonson Per, Humire Patricia, Gustafsson Jan-Åke, ;2016;Methods in molecular biology (Clifton, N.J.);1366;425-430; 26585154