C57BL/6N-Tyk2tm2a(EUCOMM)Hmgu/Ieg

Status

Available to order

EMMA IDEM:11178
International strain nameC57BL/6N-Tyk2tm2a(EUCOMM)Hmgu/Ieg
Alternative nameHEPD0809_8_G11
Strain typeTargeted Mutant Strains
Allele/Transgene symbolTyk2tm2a(EUCOMM)Hmgu
Gene/Transgene symbolTyk2
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH)
Provider affiliationInstitute of Experimental Genetics, Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH)
Genetic informationThis mouse line originates from EUCOMM ES clone HEPD0809_8_G11. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreHelmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany
Animals used for archivingheterozygous C57BL/6N

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • enlarged thymus / IMPC
  • abnormal seminal vesicle morphology / IMPC
  • decreased plasmacytoid dendritic cell number / IMPC
  • abnormal pancreas morphology / IMPC
  • decreased heart left ventricle size / IMPC
  • abnormal ovary morphology / IMPC
  • enlarged spleen / IMPC
MGI phenotypes (gene matching)
  • increased body weight / MGI
  • obese / MGI
  • increased circulating free fatty acid level / MGI
  • abnormal body temperature homeostasis / MGI
  • decreased IgG level / MGI
  • increased circulating insulin level / MGI
  • abnormal T cell differentiation / MGI
  • increased susceptibility to viral infection / MGI
  • abnormal T cell physiology / MGI
  • abnormal brown adipose tissue morphology / MGI
  • abnormal cell cycle / MGI
  • decreased susceptibility to induced arthritis / MGI
  • abnormal nitric oxide homeostasis / MGI
  • increased cholesterol level / MGI
  • decreased energy expenditure / MGI
  • abnormal response to infection / MGI
  • increased susceptibility to parasitic infection / MGI
  • impaired glucose tolerance / MGI
  • abnormal T-helper 1 physiology / MGI
  • abnormal mitochondrial physiology / MGI
  • abnormal common myeloid progenitor cell morphology / MGI
  • decreased IgG1 level / MGI
  • decreased IgG2a level / MGI
  • decreased interferon-gamma secretion / MGI
  • increased circulating interleukin-12 level / MGI
  • abnormal splenocyte physiology / MGI
  • increased susceptibility to viral infection induced morbidity/mortality / MGI
  • impaired adaptive thermogenesis / MGI
  • decreased macrophage nitric oxide production / MGI
  • abnormal fat cell differentiation / MGI
  • disorganized mitochondrial cristae / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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