B6.Cg-Ccr1tm1Gao Ccr5tm1Blck/Biat

Status

Available to order

EMMA IDEM:11147
Citation informationRRID:IMSR_EM:11147 

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International strain nameB6.Cg-Ccr1tm1Gao Ccr5tm1Blck/Biat
Alternative name15-B
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolCcr1tm1Gao, Ccr5tm1Blck
Gene/Transgene symbolCcr1, Ccr5

Information from provider

ProviderBruno Luckow
Provider affiliationNephrologisches Zentrum, Arbeitsgruppe Klinische Biochemie, Klinikum der Universitaet Muenchen, Medizinische Klinik und Poliklinik IV
Genetic informationThe chemokine receptors Ccr1 and Ccr5 have been inactivated by homologous recombination in ES cells and the resulting single knock-out mice have been crossed to generate the Ccr1/Ccr5 double knock-out mice. The Ccr1/Ccr5 double-deficient mice have been backcrossed to the C57BL/6NCrl genetic background. They contain a lacZ reporter gene at the inactivated Ccr5 locus.
Phenotypic informationHomozygous:
Homozygous animals appear healthy and fertile and if unchallenged show no obvious phenotype. So far only tested in a kidney transplantation experiment. Surprisingly, weaker phenotypic effects than both single knock-outs as if the 2 deficiencies would partially neutralize each other.

Heterozygous:
Unknown, but most likely wildtype phenotype.
Breeding historyN14+F3
References
  • Impaired host defense, hematopoiesis, granulomatous inflammation and type 1-type 2 cytokine balance in mice lacking CC chemokine receptor 1.;Gao J L, Wynn T A, Chang Y, Lee E J, Broxmeyer H E, Cooper S, Tiffany H L, Westphal H, Kwon-Chung J, Murphy P M, ;1997;The Journal of experimental medicine;185;1959-68; 9166425
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisednot known

Information from EMMA

Archiving centreUniversity of Veterinary Medicine, Vienna, Austria
Animals used for archivinghomozygous Other (please specify below) males

Disease and phenotype information

MGI phenotypes (allele matching)
  • altered response to myocardial infarction / MGI
  • abnormal leukocyte adhesion / MGI
  • abnormal cellular extravasation / MGI
  • decreased mast cell number / MGI
  • decreased susceptibility to type III hypersensitivity reaction / MGI
  • abnormal Kupffer cell morphology / MGI
  • impaired hematopoiesis / MGI
  • abnormal neutrophil physiology / MGI
  • granulomatous inflammation / MGI
  • increased susceptibility to parasitic infection / MGI
  • immune system phenotype / MGI
  • increased susceptibility to fungal infection / MGI
  • increased length of allograft survival / MGI
MGI phenotypes (gene matching)
  • decreased mast cell number / MGI
  • altered response to myocardial infarction / MGI
  • impaired hematopoiesis / MGI
  • lung inflammation / MGI
  • decreased airway responsiveness / MGI
  • decreased susceptibility to viral infection / MGI
  • decreased susceptibility to bacterial infection / MGI
  • abnormal macrophage physiology / MGI
  • abnormal neutrophil physiology / MGI
  • granulomatous inflammation / MGI
  • glomerulonephritis / MGI
  • increased urine protein level / MGI
  • abnormal leukocyte adhesion / MGI
  • increased length of allograft survival / MGI
  • decreased susceptibility to experimental autoimmune encephalomyelitis / MGI
  • increased susceptibility to parasitic infection / MGI
  • glomerulosclerosis / MGI
  • abnormal renal glomerulus morphology / MGI
  • immune system phenotype / MGI
  • increased susceptibility to fungal infection / MGI
  • increased blood urea nitrogen level / MGI
  • decreased susceptibility to type III hypersensitivity reaction / MGI
  • increased susceptibility to type IV hypersensitivity reaction / MGI
  • decreased CD4-positive, alpha beta T cell number / MGI
  • decreased CD8-positive, alpha-beta T cell number / MGI
  • abnormal Kupffer cell morphology / MGI
  • increased IgG2a level / MGI
  • increased tumor necrosis factor secretion / MGI
  • decreased tumor necrosis factor secretion / MGI
  • increased interferon-gamma secretion / MGI
  • decreased circulating interferon-gamma level / MGI
  • decreased interleukin-10 secretion / MGI
  • increased interleukin-12 secretion / MGI
  • decreased interleukin-13 secretion / MGI
  • impaired neutrophil recruitment / MGI
  • abnormal chemokine secretion / MGI
  • cecum inflammation / MGI
  • decreased susceptibility to bacterial infection induced morbidity/mortality / MGI
  • abnormal cellular extravasation / MGI
  • abnormal circulating chemokine level / MGI
  • increased macrophage nitric oxide production / MGI
  • glomerular crescent / MGI
  • altered response to myocardial infarction / MGI
  • abnormal locomotor behavior / MGI
  • abnormal spatial learning / MGI
  • abnormal cardiovascular system physiology / MGI
  • decreased inflammatory response / MGI
  • decreased susceptibility to viral infection / MGI
  • increased susceptibility to bacterial infection / MGI
  • abnormal CD4-positive, alpha beta T cell morphology / MGI
  • abnormal leukocyte physiology / MGI
  • abnormal conditioned taste aversion behavior / MGI
  • abnormal cytokine secretion / MGI
  • liver failure / MGI
  • increased alcohol consumption / MGI
  • abnormal leukocyte adhesion / MGI
  • nervous system phenotype / MGI
  • abnormal nervous system physiology / MGI
  • abnormal glial cell physiology / MGI
  • impaired macrophage chemotaxis / MGI
  • increased length of allograft survival / MGI
  • abnormal CD8-positive, alpha beta T cell morphology / MGI
  • decreased T cell proliferation / MGI
  • decreased susceptibility to injury / MGI
  • cardiovascular system phenotype / MGI
  • behavior/neurological phenotype / MGI
  • reproductive system phenotype / MGI
  • increased susceptibility to fungal infection / MGI
  • abnormal heart size / MGI
  • corneal vascularization / MGI
  • increased susceptibility to type IV hypersensitivity reaction / MGI
  • increased NK T cell number / MGI
  • abnormal NK T cell physiology / MGI
  • decreased NK cell number / MGI
  • abnormal Kupffer cell morphology / MGI
  • abnormal long term spatial reference memory / MGI
  • increased IgG1 level / MGI
  • decreased susceptibility to induced colitis / MGI
  • increased interferon-gamma secretion / MGI
  • decreased interleukin-1 beta secretion / MGI
  • increased interleukin-4 secretion / MGI
  • decreased interleukin-6 secretion / MGI
  • abnormal cytokine level / MGI
  • decreased susceptibility to endotoxin shock / MGI
  • increased physiological sensitivity to xenobiotic / MGI
  • abnormal astrocyte physiology / MGI
  • abnormal Ito cell morphology / MGI
  • abnormal cellular extravasation / MGI
  • abnormal hepatocyte physiology / MGI
  • decreased right ventricle systolic pressure / MGI
  • mortality/aging / MGI
  • increased fluid intake / MGI
  • decreased microglial cell activation / MGI

Literature references

  • Impaired host defense, hematopoiesis, granulomatous inflammation and type 1-type 2 cytokine balance in mice lacking CC chemokine receptor 1.;Gao J L, Wynn T A, Chang Y, Lee E J, Broxmeyer H E, Cooper S, Tiffany H L, Westphal H, Kwon-Chung J, Murphy P M, ;1997;The Journal of experimental medicine;185;1959-68; 9166425

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