C57BL/6NTac-Startm1(EGFP/Cre/ERT2)Wtsi/WtsiH

Status

Available to order

EMMA IDEM:11127
International strain nameC57BL/6NTac-Startm1(EGFP/Cre/ERT2)Wtsi/WtsiH
Alternative nameCEPD0062_5_A06
Strain typeTargeted Mutant Strains : Knock-in
Allele/Transgene symbolStartm1(EGFP/Cre/ERT2)Wtsi
Gene/Transgene symbolStar

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from EUCOMM ES clone CEPD0062_5_A06. For further details on the construction of this clone see the page at the IMPC portal.
Quality Control/Disclaimer: The structure of the targeted mutation is not fully verified. It is recommended that the recipient confirms the mutation structure by Southern blotting. The Cre expression pattern is expected to mirror that of the host gene, but this may not be fully described and/or may be modified in the targeted allele. Although characterisation of the Cre expression pattern is an objective of EUCOMMTools this is an ongoing process which may be incomplete. It is therefore recommended that the recipient verifies the Cre expression pattern. For the tm1(EGFP/Cre/ERT2) type allele, if the promoter-driven selection cassette is flanked with Rox sites, it may be removed using Dre recombinase. Please be aware that the strain description may be subject to change. For the most recent description please consult the information pages for the appropriate product details at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom
Animals used for archivingheterozygous C57BL/6NTacUSA, heterozygous C57BL/6NTacUSA
Breeding at archiving centreC57BL/6NTac background

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

    • Non-classic congenital lipoid adrenal hyperplasia due to STAR deficency / Orphanet_325529
    • Classic congenital lipoid adrenal hyperplasia due to STAR deficency / Orphanet_325524
    • Congenital sodium diarrhea / Orphanet_103908
    • Chronic infantile diarrhea due to guanylate cyclase 2C overactivity / Orphanet_314373
    • Intestinal obstruction in the newborn due to guanylate cyclase 2C deficiency / Orphanet_314376
MGI phenotypes (gene matching)
  • abnormal adrenal gland morphology / MGI
  • abnormal uterus morphology / MGI
  • abnormal ovary morphology / MGI
  • abnormal ovarian folliculogenesis / MGI
  • absent corpus luteum / MGI
  • abnormal testis morphology / MGI
  • Leydig cell hyperplasia / MGI
  • arrest of spermatogenesis / MGI
  • small seminal vesicle / MGI
  • decreased body weight / MGI
  • cyanosis / MGI
  • postnatal growth retardation / MGI
  • increased circulating corticotropin-releasing hormone level / MGI
  • decreased circulating corticosterone level / MGI
  • decreased circulating aldosterone level / MGI
  • small prostate gland / MGI
  • abnormal Leydig cell morphology / MGI
  • male pseudohermaphroditism / MGI
  • enlarged ovary / MGI
  • increased adrenocorticotropin level / MGI
  • prostate gland hypoplasia / MGI
  • seminal vesicle hypoplasia / MGI
  • abnormal adrenal cortex morphology / MGI
  • adrenal cortical hyperplasia / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • neonatal lethality, incomplete penetrance / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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