- disorganized extraembryonic tissue / MGI
- absent extraembryonic ectoderm / MGI
- abnormal inner cell mass morphology / MGI
- no phenotypic analysis / MGI
- abnormal inner cell mass apoptosis / MGI
- embryonic lethality between implantation and somite formation, complete penetrance / MGI
- absent embryonic epiblast / MGI
- absent primitive endoderm / MGI
STOCK Nanogtm1.1Asim/Cnrm
Status | Available to order |
EMMA ID | EM:11120 |
Citation information | RRID:IMSR_EM:11120 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
International strain name | STOCK Nanogtm1.1Asim/Cnrm |
Alternative name | Nanog deltaOBS5 |
Strain type | Targeted Mutant Strains : Other targeted |
Allele/Transgene symbol | Nanogtm1.1Asim |
Gene/Transgene symbol | Nanog |
Information from provider
Provider | Antonio Simeone |
Provider affiliation | IGB-CNR |
Genetic information | Mutagenesis of Otx2 binding site on Nanog promoter at -144 respect to methionine 1. |
Phenotypic information | Homozygous:Mice are viable and fertile, but, compared to wild-type, the number of mice per litter was reduced by about 50%. This reduction was also observed at E12.5 and E6.5.Heterozygous:Mice are viable and fertile |
References |
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Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
MGI phenotypes (gene matching)
Literature references
- Loss of the Otx2-Binding Site in the Nanog Promoter Affects the Integrity of Embryonic Stem Cell Subtypes and Specification of Inner Cell Mass-Derived Epiblast.;Acampora Dario, Omodei Daniela, Petrosino Giuseppe, Garofalo Arcomaria, Savarese Marco, Nigro Vincenzo, Di Giovannantonio Luca Giovanni, Mercadante Vincenzo, Simeone Antonio, ;2016;Cell reports;15;2651-64; 27292645
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