IMPC phenotypes (gene matching)
B6.Cg-Zfp36tm1Pjb/Flmg
| Status | Available to order |
| EMMA ID | EM:11082 |
| International strain name | B6.Cg-Zfp36tm1Pjb/Flmg |
| Alternative name | B6.Cg-Zfp36 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Zfp36tm1Pjb |
| Gene/Transgene symbol | Zfp36 |
Information from provider
| Provider | Perry Blackshear |
| Provider affiliation | Rall Building , National Institute of Environmental Health Sciences (NIEHS) |
| Genetic information | Exon 2 was disrupted by the insertion of a neomycin selection cassette. Multiple stop codons were generated upstream of sequence encoding two putative zinc fingers. Northern blot analysis showed an absence of normal transcript and identified an aberrant transcript containing neo. Neither normal nor truncated protein was detected by Western blot analysis of mouse embryonic fibroblasts derived from homozygous mutant mice. |
| Phenotypic information | Homozygous:Tristetraprolin (Ttp, Zfp36) knock-out mice develop a complex and severe inflammatory syndrome that involves arthritis, autoimmunity, cachexia, dermatitis, and myeloid hyperplasia.Heterozygous:TTP heterozygous mice are normal and fertile. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | B.S.R.C. Alexander Fleming, Vari, Greece |
| Animals used for archiving | heterozygous C57BL/6 |
Disease and phenotype information
MGI allele-associated human disease models
MGI phenotypes (allele matching)
- increased neutrophil cell number / MGI
- increased monocyte cell number / MGI
- increased granulocyte number / MGI
- abnormal vasodilation / MGI
- vascular inflammation / MGI
- abnormal macrophage physiology / MGI
- decreased systemic arterial blood pressure / MGI
- arthritis / MGI
- oxidative stress / MGI
- abnormal nitric oxide homeostasis / MGI
- decreased lymphocyte cell number / MGI
- homeostasis/metabolism phenotype / MGI
- thrombocytosis / MGI
- increased cellular sensitivity to oxidative stress / MGI
- increased leukocyte cell number / MGI
- extramedullary hematopoiesis / MGI
- alopecia / MGI
- enlarged spleen / MGI
- spleen hyperplasia / MGI
- enlarged lymph nodes / MGI
- dermatitis / MGI
- decreased body weight / MGI
- postnatal growth retardation / MGI
- thymus hypoplasia / MGI
- conjunctivitis / MGI
- heart inflammation / MGI
- liver inflammation / MGI
- premature death / MGI
- abnormal thymus cortex morphology / MGI
- abnormal thymus medulla morphology / MGI
- abnormal renal glomerulus morphology / MGI
- absent subcutaneous adipose tissue / MGI
MGI phenotypes (gene matching)
- increased leukocyte cell number / MGI
- increased neutrophil cell number / MGI
- increased monocyte cell number / MGI
- extramedullary hematopoiesis / MGI
- increased granulocyte number / MGI
- alopecia / MGI
- enlarged spleen / MGI
- spleen hyperplasia / MGI
- enlarged lymph nodes / MGI
- dermatitis / MGI
- decreased body weight / MGI
- abnormal vasodilation / MGI
- postnatal growth retardation / MGI
- thymus hypoplasia / MGI
- conjunctivitis / MGI
- heart inflammation / MGI
- liver inflammation / MGI
- vascular inflammation / MGI
- decreased inflammatory response / MGI
- premature death / MGI
- abnormal thymus cortex morphology / MGI
- abnormal thymus medulla morphology / MGI
- abnormal macrophage physiology / MGI
- decreased systemic arterial blood pressure / MGI
- arthritis / MGI
- decreased susceptibility to induced arthritis / MGI
- oxidative stress / MGI
- abnormal nitric oxide homeostasis / MGI
- decreased susceptibility to experimental autoimmune encephalomyelitis / MGI
- decreased lymphocyte cell number / MGI
- abnormal renal glomerulus morphology / MGI
- homeostasis/metabolism phenotype / MGI
- thrombocytosis / MGI
- increased cellular sensitivity to oxidative stress / MGI
- absent subcutaneous adipose tissue / MGI
Literature references
- A pathogenetic role for TNF alpha in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiency.;Taylor G A, Carballo E, Lee D M, Lai W S, Thompson M J, Patel D D, Schenkman D I, Gilkeson G S, Broxmeyer H E, Haynes B F, Blackshear P J, ;1996;Immunity;4;445-54; 8630730
- Endothelial dysfunction in tristetraprolin-deficient mice is not caused by enhanced tumor necrosis factor-α expression.;Bollmann Franziska, Wu Zhixiong, Oelze Matthias, Siuda Daniel, Xia Ning, Henke Jenny, Daiber Andreas, Li Huige, Stumpo Deborah J, Blackshear Perry J, Kleinert Hartmut, Pautz Andrea, ;2014;The Journal of biological chemistry;289;15653-65; 24727475