C57BL/6N-Atm1Brd Gprc5btm1c(EUCOMM)Wtsi/WtsiBiat

Status

Available to order

EMMA IDEM:11063
International strain nameC57BL/6N-Atm1Brd Gprc5btm1c(EUCOMM)Wtsi/WtsiBiat
Alternative nameC57BL/6N-A Gprc5b/WtsiBiat
Strain typeTargeted Mutant Strains : Conditional mutation
Allele/Transgene symbolGprc5btm1c(EUCOMM)Wtsi
Gene/Transgene symbolGprc5b

Information from provider

ProviderThomas Rülicke
Provider affiliationInstitute of Laboratory Animal Science and Biomodels Austria, University of Veterinary Medicine
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0534_1_A10. For further details see the relevant page on the IMPC portal. After breeding with a flp recombinase deleter line, the original targeted tm1a allele (knock-out first allele) was converted into a conditional tm1c allele.
Phenotypic informationHomozygous:
Hemolysis; for more details see https://www.mousephenotype.org/data/genes/MGI:1927596#section-associations

Heterozygous:
unknown
Breeding historyThe tm1a mutant was crossed 2 times with CAG-FLPe mice, and the resulting offspring once with C57BL/6N mice. Backcrossed: 1 generation to C57BL/6N.
ReferencesNone available
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisednot known

Information from EMMA

Archiving centreUniversity of Veterinary Medicine, Vienna, Austria
Animals used for archivingheterozygous C57BL/6N
Breeding at archiving centreThe strain was produced at Vetmeduni Vienna for an EMMA Customer w/o charging

Disease and phenotype information

IMPC phenotypes (gene matching)
  • enlarged epididymis / IMPC
  • abnormal liver morphology / IMPC
  • abnormal epididymis morphology / IMPC
MGI phenotypes (gene matching)
  • hypoactivity / MGI
  • abnormal behavior / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • neonatal lethality, incomplete penetrance / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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