C57BL/6NTac-Tm6sf2tm1a(KOMP)Wtsi/H

Status

Available to order

EMMA IDEM:11054
Citation informationRRID:IMSR_EM:11054 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6NTac-Tm6sf2tm1a(KOMP)Wtsi/H
Alternative nameEPD0097_3_A03
Strain typeTargeted Mutant Strains
Allele/Transgene symbolTm6sf2tm1a(KOMP)Wtsi
Gene/Transgene symbolTm6sf2
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from KOMP ES clone EPD0097_3_A03. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom
Animals used for archivingheterozygous C57BL/6NTac (USA) males
Breeding at archiving centreC57BL/6NTac background

Disease and phenotype information

MGI phenotypes (allele matching)
  • abnormal cholesterol homeostasis / MGI
  • increased liver triglyceride level / MGI
  • decreased circulating LDL cholesterol level / MGI
  • decreased circulating HDL cholesterol level / MGI
  • abnormal enterocyte morphology / MGI
  • increased circulating triglyceride level / MGI
  • hepatic steatosis / MGI
  • decreased intestinal cholesterol absorption / MGI
  • increased circulating alanine transaminase level / MGI
  • decreased circulating VLDL triglyceride level / MGI
  • decreased circulating cholesterol level / MGI
  • increased triglyceride level / MGI
  • abnormal intestinal lipid absorption / MGI
  • abnormal circulating apolipoprotein level / MGI

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

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Practical information

Example health report
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Material Transfer Agreement (MTA)
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