- abnormal pericardium morphology / MGI
- increased cell proliferation / MGI
- megacephaly / MGI
- prostate gland hyperplasia / MGI
- abnormal thyroid gland morphology / MGI
- lymphoid hyperplasia / MGI
- enlarged spleen / MGI
- enlarged thymus / MGI
- abnormal olfactory bulb morphology / MGI
- altered metastatic potential / MGI
- abnormal brain development / MGI
- open neural tube / MGI
- wavy neural tube / MGI
- abnormal uterus morphology / MGI
- abnormal prostate gland morphology / MGI
- prostate gland epithelial hyperplasia / MGI
- abnormal prostate gland epithelium morphology / MGI
- decreased body size / MGI
- increased metastatic potential / MGI
- abnormal social investigation / MGI
- increased stereotypic behavior / MGI
- impaired balance / MGI
- abnormal embryo development / MGI
- abnormal somite development / MGI
- abnormal gastrulation / MGI
- decreased embryo size / MGI
- incomplete embryo turning / MGI
- abnormal placenta morphology / MGI
- abnormal allantois morphology / MGI
- embryonic growth arrest / MGI
- increased mammary adenocarcinoma incidence / MGI
- increased malignant tumor incidence / MGI
- abnormal tumor incidence / MGI
- increased tumor incidence / MGI
- increased T cell derived lymphoma incidence / MGI
- increased leukemia incidence / MGI
- increased adrenal gland tumor incidence / MGI
- increased carcinoma incidence / MGI
- increased pheochromocytoma incidence / MGI
- premature death / MGI
- abnormal developmental patterning / MGI
- abnormal embryonic tissue morphology / MGI
- increased brain weight / MGI
- abnormal CNS synaptic transmission / MGI
- abnormal seminiferous tubule morphology / MGI
- abnormal lymph node B cell domain morphology / MGI
- increased teratoma incidence / MGI
- abnormal synaptic depression / MGI
- increased hemangioma incidence / MGI
- colon polyps / MGI
- increased liver adenoma incidence / MGI
- astrocytosis / MGI
- kinked neural tube / MGI
- increased thyroid adenoma incidence / MGI
- abnormal microglial cell physiology / MGI
- decreased aggression towards males / MGI
- embryonic growth retardation / MGI
- disorganized embryonic tissue / MGI
- failure of initiation of embryo turning / MGI
- cardia bifida / MGI
- increased incidence of tumors by ionizing radiation induction / MGI
- enlarged allantois / MGI
- abnormal thyroid follicular cell morphology / MGI
- increased endometrial carcinoma incidence / MGI
- abnormal behavior / MGI
- abnormal brain vasculature morphology / MGI
- abnormal rostral-caudal axis patterning / MGI
- increased brain size / MGI
- abnormal cell physiology / MGI
- increased mammary adenoacanthoma incidence / MGI
- intestine polyps / MGI
- lymph node hyperplasia / MGI
- enlarged Peyer's patches / MGI
- abnormal cerebral hemisphere morphology / MGI
- embryonic lethality / MGI
- enlarged cerebellum / MGI
- endometrium hyperplasia / MGI
- decreased prepulse inhibition / MGI
- increased prostate intraepithelial neoplasia incidence / MGI
- increased uterus carcinoma incidence / MGI
- failure of chorioallantoic fusion / MGI
- abnormal hippocampus granule cell morphology / MGI
- abnormal hippocampus pyramidal cell morphology / MGI
- abnormal cerebral cortex pyramidal cell morphology / MGI
- increased oligodendrocyte number / MGI
- increased gastrointestinal tumor incidence / MGI
- increased mammary gland tumor incidence / MGI
- increased stomach tumor incidence / MGI
- increased hamartoma incidence / MGI
- increased thyroid tumor incidence / MGI
- increased thyroid carcinoma incidence / MGI
- increased prostate gland tumor incidence / MGI
- increased fibroadenoma incidence / MGI
- embryonic lethality, complete penetrance / MGI
- embryonic lethality between implantation and somite formation, complete penetrance / MGI
- embryonic lethality during organogenesis, complete penetrance / MGI
- prenatal lethality, incomplete penetrance / MGI
- embryonic lethality during organogenesis, incomplete penetrance / MGI
- increased astrocyte number / MGI
- increased lymphoma incidence / MGI
STOCK Ptentm Tg(Alb1-cre) Tg(Alb1-HCVN)35Sml/Orl
Status | Available to order |
EMMA ID | EM:11052 |
International strain name | STOCK Ptentm Tg(Alb1-cre) Tg(Alb1-HCVN)35Sml/Orl |
Alternative name | HCV +/+ AlbCRE +/+ PTEN flox/flox |
Strain type | Transgenic Strains |
Allele/Transgene symbol | Tg(Alb1-HCVN)35Sml, Ptentm-flox, Tg(Alb1-cre) |
Gene/Transgene symbol | Tg(Alb1-HCVN)35Sml, Pten, Tg(Alb1-cre) |
Information from provider
Provider | Hervé LERAT |
Provider affiliation | Equipe 18, IMRB, Inserm U955 |
Genetic information | These mice are conditionally invalidated for PTEN (exon 4 and 5 are floxed). They are also transgenic for cre recombinase (albumin promoter) and transgenic for the full hepatitis C virus (HCV) ORF (albumin promoter). They were generated by crossing FL-N/35 mice with PTEN flox/flox and Alb CRE+/+ mice. These mice are invalidated for PTEN in their liver and express all HCV proteins (genotype 1b) in their liver. |
Phenotypic information | Homozygous:Severe non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC).Heterozygous:Severe NASH and HCC. |
References | None available |
Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | yes |
Immunocompromised | no |
Information from EMMA
Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Squamous cell carcinoma of salivary glands / Orphanet_500481
- Squamous cell carcinoma of the oral cavity / Orphanet_502363
- Squamous cell carcinoma of the larynx / Orphanet_494550
- Squamous cell carcinoma of the oropharynx / Orphanet_500478
- Squamous cell carcinoma of the nasal cavity and paranasal sinuses / Orphanet_500464
- Squamous cell carcinoma of the hypopharynx / Orphanet_494547
- Squamous cell carcinoma of the lip / Orphanet_502366
- Activated PI3K-delta syndrome / Orphanet_397596
- Lhermitte-Duclos disease / Orphanet_65285
- Cowden syndrome / Orphanet_201
- Bannayan-Riley-Ruvalcaba syndrome / Orphanet_109
- Macrocephaly-intellectual disability-autism syndrome / Orphanet_210548
- Proteus-like syndrome / Orphanet_2969
- Segmental outgrowth-lipomatosis-arteriovenous malformation-epidermal nevus syndrome / Orphanet_137608
- Proteus syndrome / Orphanet_744
- Bilateral frontoparietal polymicrogyria / Orphanet_101070
MGI phenotypes (gene matching)
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