STOCK Ptentm Tg(Alb1-cre) Tg(Alb1-HCVN)35Sml/Orl

Status

Available to order

EMMA IDEM:11052
Citation informationRRID:IMSR_EM:11052 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameSTOCK Ptentm Tg(Alb1-cre) Tg(Alb1-HCVN)35Sml/Orl
Alternative nameHCV +/+ AlbCRE +/+ PTEN flox/flox
Strain typeTransgenic Strains
Allele/Transgene symbolTg(Alb1-HCVN)35Sml, Ptentm-flox, Tg(Alb1-cre)
Gene/Transgene symbolTg(Alb1-HCVN)35Sml, Pten, Tg(Alb1-cre)

Information from provider

ProviderHervé LERAT
Provider affiliationEquipe 18, IMRB, Inserm U955
Genetic informationThese mice are conditionally invalidated for PTEN (exon 4 and 5 are floxed). They are also transgenic for cre recombinase (albumin promoter) and transgenic for the full hepatitis C virus (HCV) ORF (albumin promoter). They were generated by crossing FL-N/35 mice with PTEN flox/flox and Alb CRE+/+ mice. These mice are invalidated for PTEN in their liver and express all HCV proteins (genotype 1b) in their liver.
Phenotypic informationHomozygous:
Severe non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC).

Heterozygous:
Severe NASH and HCC.
ReferencesNone available
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredyes
Immunocompromisedno

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (gene matching)
  • abnormal pericardium morphology / MGI
  • increased cell proliferation / MGI
  • megacephaly / MGI
  • prostate gland hyperplasia / MGI
  • abnormal thyroid gland morphology / MGI
  • lymphoid hyperplasia / MGI
  • enlarged spleen / MGI
  • enlarged thymus / MGI
  • abnormal olfactory bulb morphology / MGI
  • altered metastatic potential / MGI
  • abnormal brain development / MGI
  • open neural tube / MGI
  • wavy neural tube / MGI
  • abnormal uterus morphology / MGI
  • abnormal prostate gland morphology / MGI
  • prostate gland epithelial hyperplasia / MGI
  • abnormal prostate gland epithelium morphology / MGI
  • decreased body size / MGI
  • increased metastatic potential / MGI
  • abnormal social investigation / MGI
  • increased stereotypic behavior / MGI
  • impaired balance / MGI
  • abnormal embryo development / MGI
  • abnormal somite development / MGI
  • abnormal gastrulation / MGI
  • decreased embryo size / MGI
  • incomplete embryo turning / MGI
  • abnormal placenta morphology / MGI
  • abnormal allantois morphology / MGI
  • embryonic growth arrest / MGI
  • increased mammary adenocarcinoma incidence / MGI
  • increased malignant tumor incidence / MGI
  • abnormal tumor incidence / MGI
  • increased tumor incidence / MGI
  • increased T cell derived lymphoma incidence / MGI
  • increased leukemia incidence / MGI
  • increased adrenal gland tumor incidence / MGI
  • increased carcinoma incidence / MGI
  • increased pheochromocytoma incidence / MGI
  • premature death / MGI
  • abnormal developmental patterning / MGI
  • abnormal embryonic tissue morphology / MGI
  • increased brain weight / MGI
  • abnormal CNS synaptic transmission / MGI
  • abnormal seminiferous tubule morphology / MGI
  • abnormal lymph node B cell domain morphology / MGI
  • increased teratoma incidence / MGI
  • abnormal synaptic depression / MGI
  • increased hemangioma incidence / MGI
  • colon polyps / MGI
  • increased liver adenoma incidence / MGI
  • astrocytosis / MGI
  • kinked neural tube / MGI
  • increased thyroid adenoma incidence / MGI
  • abnormal microglial cell physiology / MGI
  • decreased aggression towards males / MGI
  • embryonic growth retardation / MGI
  • disorganized embryonic tissue / MGI
  • failure of initiation of embryo turning / MGI
  • cardia bifida / MGI
  • increased incidence of tumors by ionizing radiation induction / MGI
  • enlarged allantois / MGI
  • abnormal thyroid follicular cell morphology / MGI
  • increased endometrial carcinoma incidence / MGI
  • abnormal behavior / MGI
  • abnormal brain vasculature morphology / MGI
  • abnormal rostral-caudal axis patterning / MGI
  • increased brain size / MGI
  • abnormal cell physiology / MGI
  • increased mammary adenoacanthoma incidence / MGI
  • intestine polyps / MGI
  • lymph node hyperplasia / MGI
  • enlarged Peyer's patches / MGI
  • abnormal cerebral hemisphere morphology / MGI
  • embryonic lethality / MGI
  • enlarged cerebellum / MGI
  • endometrium hyperplasia / MGI
  • decreased prepulse inhibition / MGI
  • increased prostate intraepithelial neoplasia incidence / MGI
  • increased uterus carcinoma incidence / MGI
  • failure of chorioallantoic fusion / MGI
  • abnormal hippocampus granule cell morphology / MGI
  • abnormal hippocampus pyramidal cell morphology / MGI
  • abnormal cerebral cortex pyramidal cell morphology / MGI
  • increased oligodendrocyte number / MGI
  • increased gastrointestinal tumor incidence / MGI
  • increased mammary gland tumor incidence / MGI
  • increased stomach tumor incidence / MGI
  • increased hamartoma incidence / MGI
  • increased thyroid tumor incidence / MGI
  • increased thyroid carcinoma incidence / MGI
  • increased prostate gland tumor incidence / MGI
  • increased fibroadenoma incidence / MGI
  • embryonic lethality, complete penetrance / MGI
  • embryonic lethality between implantation and somite formation, complete penetrance / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI
  • prenatal lethality, incomplete penetrance / MGI
  • embryonic lethality during organogenesis, incomplete penetrance / MGI
  • increased astrocyte number / MGI
  • increased lymphoma incidence / MGI

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