C57BL/6N-Cd19em2(IMPC)Ics/Ics

Status

Available to order

EMMA IDEM:11040
International strain nameC57BL/6N-Cd19em2(IMPC)Ics/Ics
Alternative name
Strain typeEndonuclease-mediated
Allele/Transgene symbolCd19em2(IMPC)Ics
Gene/Transgene symbolCd19

Information from provider

Provider ICS, Institut Clinique de la Souris
Provider affiliationICS, Institut Clinique de la Souris
Genetic informationThis mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (allele matching)
  • increased monocyte cell number / IMPC
  • decreased lymphocyte cell number / IMPC
IMPC phenotypes (gene matching)
  • increased monocyte cell number / IMPC
  • decreased lymphocyte cell number / IMPC
MGI phenotypes (gene matching)
  • decreased neutrophil cell number / MGI
  • demyelination / MGI
  • thick dermal layer / MGI
  • abnormal humoral immune response / MGI
  • decreased IgM level / MGI
  • decreased IgA level / MGI
  • abnormal B cell differentiation / MGI
  • no abnormal phenotype detected / MGI
  • abnormal B cell physiology / MGI
  • abnormal immunoglobulin level / MGI
  • decreased IgE level / MGI
  • decreased anti-nuclear antigen antibody level / MGI
  • decreased anti-double stranded DNA antibody level / MGI
  • increased susceptibility to experimental autoimmune encephalomyelitis / MGI
  • decreased B-1 B cell number / MGI
  • decreased B cell number / MGI
  • decreased B cell proliferation / MGI
  • increased susceptibility to injury / MGI
  • increased CD8-positive, alpha-beta T cell number / MGI
  • absent spleen germinal center / MGI
  • decreased IgG1 level / MGI
  • decreased IgG2a level / MGI
  • decreased IgG2b level / MGI
  • decreased IgG3 level / MGI
  • decreased circulating tumor necrosis factor level / MGI
  • decreased tumor necrosis factor secretion / MGI
  • increased interferon-gamma secretion / MGI
  • decreased circulating interferon-gamma level / MGI
  • decreased circulating interleukin-10 level / MGI
  • decreased circulating interleukin-6 level / MGI
  • decreased circulating interleukin-4 level / MGI
  • decreased interleukin-10 secretion / MGI
  • decreased physiological sensitivity to xenobiotic / MGI
  • increased sensitivity to induced morbidity/mortality / MGI
  • skin fibrosis / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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