IMPC phenotypes (allele matching)
C57BL/6N-Cd19em2(IMPC)Ics/Ics
| Status | Available to order |
| EMMA ID | EM:11040 |
| Citation information | RRID:IMSR_EM:11040 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6N-Cd19em2(IMPC)Ics/Ics |
| Alternative name | |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Cd19em2(IMPC)Ics |
| Gene/Transgene symbol | Cd19 |
Information from provider
| Provider | ICS, Institut Clinique de la Souris |
| Provider affiliation | ICS, Institut Clinique de la Souris |
| Genetic information | This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | ICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Common variable immunodeficiency / Orphanet_1572
MGI phenotypes (gene matching)
- decreased neutrophil cell number / MGI
- demyelination / MGI
- thick dermal layer / MGI
- abnormal humoral immune response / MGI
- decreased IgM level / MGI
- decreased IgA level / MGI
- abnormal B cell differentiation / MGI
- no abnormal phenotype detected / MGI
- abnormal B cell physiology / MGI
- abnormal immunoglobulin level / MGI
- decreased IgE level / MGI
- decreased anti-nuclear antigen antibody level / MGI
- decreased anti-double stranded DNA antibody level / MGI
- increased susceptibility to experimental autoimmune encephalomyelitis / MGI
- decreased B-1 B cell number / MGI
- decreased B cell number / MGI
- decreased B cell proliferation / MGI
- increased susceptibility to injury / MGI
- increased CD8-positive, alpha-beta T cell number / MGI
- absent spleen germinal center / MGI
- decreased IgG1 level / MGI
- decreased IgG2a level / MGI
- decreased IgG2b level / MGI
- decreased IgG3 level / MGI
- decreased circulating tumor necrosis factor level / MGI
- decreased tumor necrosis factor secretion / MGI
- increased interferon-gamma secretion / MGI
- decreased circulating interferon-gamma level / MGI
- decreased circulating interleukin-10 level / MGI
- decreased circulating interleukin-6 level / MGI
- decreased circulating interleukin-4 level / MGI
- decreased interleukin-10 secretion / MGI
- decreased physiological sensitivity to xenobiotic / MGI
- increased sensitivity to induced morbidity/mortality / MGI
- skin fibrosis / MGI