C57BL/6N-Caprin1tm3c(EUCOMM)Wtsi/WtsiPh

Status

Available to order

EMMA IDEM:11000
International strain nameC57BL/6N-Caprin1tm3c(EUCOMM)Wtsi/WtsiPh
Alternative nameEPD0989_2_A03
Strain typeTargeted Mutant Strains : Targeted Conditional
Allele/Transgene symbolCaprin1tm3c(EUCOMM)Wtsi
Gene/Transgene symbolCaprin1
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis line originates from EUCOMM ES clone EPD0989_2_A03, after breeding with a Flp recombinase deleter line to convert the original targeted allele tm3a (knock-out first allele) into a conditional allele tm3c. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
References
  • Targeted deletion of the RNA-binding protein Caprin1 leads to progressive hearing loss and impairs recovery from noise exposure in mice.;Nolan Lisa S, Chen Jing, Gonçalves Ana-Cláudia, Bullen Anwen, Towers Emily R, Steel Karen P, Dawson Sally J, Gale Jonathan E, ;2022;Scientific reports;12;2444; 35165318

Information from EMMA

Archiving centreInstitute of Molecular Genetics, Prague, Czech Republic

Disease and phenotype information

MGI phenotypes (gene matching)
  • abnormal posture / MGI
  • cyanosis / MGI
  • respiratory failure / MGI
  • increased neuron apoptosis / MGI
  • decreased fetal size / MGI
  • abnormal miniature excitatory postsynaptic currents / MGI
  • abnormal neuron physiology / MGI
  • abnormal dendrite morphology / MGI
  • abnormal synapse morphology / MGI
  • neonatal lethality, complete penetrance / MGI

Literature references

  • Targeted deletion of the RNA-binding protein Caprin1 leads to progressive hearing loss and impairs recovery from noise exposure in mice.;Nolan Lisa S, Chen Jing, Gonçalves Ana-Cláudia, Bullen Anwen, Towers Emily R, Steel Karen P, Dawson Sally J, Gale Jonathan E, ;2022;Scientific reports;12;2444; 35165318

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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