B6;C3H-Tg(Alb1-HCVN)35Sml/Orl

Status	Available to order
EMMA ID	EM:10981
International strain name	B6;C3H-Tg(Alb1-HCVN)35Sml/Orl
Alternative name	FL-N/35
Strain type	Transgenic Strains
Allele/Transgene symbol	Tg(Alb1-HCVN)35Sml
Gene/Transgene symbol	Tg(Alb1-HCVN)35Sml

Information from provider

Provider	Hervé LERAT
Provider affiliation	IMRB, Inserm U955 Equipe 18
Genetic information	Constitutive expression, limited to the liver, of all hepatitis C virus proteins.
Phenotypic information	Homozygous: Not studied Heterozygous: Liver steatosis (older than 6 months) and liver cancer (older than 13 months).
Breeding history	Always bred as heterozygotes.
References	Steatosis and liver cancer in transgenic mice expressing the structural and nonstructural proteins of hepatitis C virus.;Lerat Hervé, Honda Masao, Beard Michael R, Loesch Kim, Sun Jiaren, Yang Yan, Okuda Michiari, Gosert Rainer, Xiao Shu-Yuan, Weinman Steven A, Lemon Stanley M, ;2002;Gastroenterology;122;352-65; 11832450
Homozygous fertile	yes
Homozygous viable	yes
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	Institut de Transgenose, INTRAGENE, Orléans, France
Animals used for archiving	heterozygous C57BL/6J

Literature references

Steatosis and liver cancer in transgenic mice expressing the structural and nonstructural proteins of hepatitis C virus.;Lerat Hervé, Honda Masao, Beard Michael R, Loesch Kim, Sun Jiaren, Yang Yan, Okuda Michiari, Gosert Rainer, Xiao Shu-Yuan, Weinman Steven A, Lemon Stanley M, ;2002;Gastroenterology;122;352-65; 11832450

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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