B6;D2-Tg(Slc5a2-cre)1Tauc/Orl

Status	Available to order
EMMA ID	EM:01098
International strain name	B6;D2-Tg(Slc5a2-cre)1Tauc/Orl
Alternative name	iL-sglt2-Cre
Strain type	Transgenic Strains
Allele/Transgene symbol	Tg(Slc5a2-cre)1Tauc
Gene/Transgene symbol	Tg(Slc5a2-cre)1Tauc

Information from provider

Provider	Isabelle Rubera
Provider affiliation	UMR-CNRS 6548 Laboratoire de Physiologie Cellulaire et Moléculaire
Genetic information	Specific expression of the cre recombinase in the kidney proximal tubule.
References	Specific Cre/Lox recombination in the mouse proximal tubule.;Rubera Isabelle, Poujeol Chantal, Bertin Guillaume, Hasseine Lilia, Counillon Laurent, Poujeol Philippe, Tauc Michel, ;2004;Journal of the American Society of Nephrology : JASN;15;2050-6; 15284291 Proximal tubular epithelial insulin receptor mediates high-fat diet-induced kidney injury.;Lee Hak Joo, Mariappan Meenalakshmi M, Norton Luke, Bakewell Terry, Feliers Denis, Oh Sae Byeol, Donati Andrew, Rubannelsonkumar Cherubina S, Venkatachalam Manjeri A, Harris Stephen E, Rubera Isabelle, Tauc Michel, Ghosh Choudhury Goutam, Kahn C Ronald, Sharma Kumar, DeFronzo Ralph A, Kasinath Balakuntalam S, ;2021;JCI insight;6;; 33400689

Information from EMMA

Archiving centre	Institut de Transgenose, INTRAGENE, Orléans, France

Literature references

Specific Cre/Lox recombination in the mouse proximal tubule.;Rubera Isabelle, Poujeol Chantal, Bertin Guillaume, Hasseine Lilia, Counillon Laurent, Poujeol Philippe, Tauc Michel, ;2004;Journal of the American Society of Nephrology : JASN;15;2050-6; 15284291
Proximal tubular epithelial insulin receptor mediates high-fat diet-induced kidney injury.;Lee Hak Joo, Mariappan Meenalakshmi M, Norton Luke, Bakewell Terry, Feliers Denis, Oh Sae Byeol, Donati Andrew, Rubannelsonkumar Cherubina S, Venkatachalam Manjeri A, Harris Stephen E, Rubera Isabelle, Tauc Michel, Ghosh Choudhury Goutam, Kahn C Ronald, Sharma Kumar, DeFronzo Ralph A, Kasinath Balakuntalam S, ;2021;JCI insight;6;e22835; 33400689
Na/K-ATPase signaling tonically inhibits sodium reabsorption in the renal proximal tubule.;Mukherji Shreya T, Brambilla Luca, Stuart Kailey B, Mayes Isabella, Kutz Laura C, Chen Yiliang, Barbosa Leandro A, Elmadbouh Ibrahim, McDermott Jeff P, Haller Steven T, Romero Michael F, Soleimani Manoocher, Liu Jiang, Shapiro Joseph I, Blanco Gustavo V, Xie Zijian, Pierre Sandrine V, ;2023;FASEB journal : official publication of the Federation of American Societies for Experimental Biology;37;; 36856735

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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