- hypoglycemia / MGI
- abnormal suckling behavior / MGI
- postnatal growth retardation / MGI
- abnormal glucose homeostasis / MGI
- decreased circulating ketone body level / MGI
- abnormal insulin secretion / MGI
- decreased circulating glucose level / MGI
- increased liver glycogen level / MGI
- mortality/aging / MGI
- postnatal lethality, incomplete penetrance / MGI
- perinatal lethality, incomplete penetrance / MGI
B6.129-Mirc36tm1.1Jcav/Orl
Status | Available to order |
EMMA ID | EM:10967 |
Citation information | RRID:IMSR_EM:10967 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
International strain name | B6.129-Mirc36tm1.1Jcav/Orl |
Alternative name | KO-miR-379/miR-410 |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Mirc36tm1.1Jcav |
Gene/Transgene symbol | Mirc36 |
Information from provider
Provider | Cavaille Jerome |
Provider affiliation | LBME-CNRS-UMR5099 |
Genetic information | A Cre-loxP-mediated deletion that removes the maternally-expressed miR-379/miR-410 gene cluster at the imprinted DlK1-Dio3 domain. |
Phenotypic information | Homozygous:UnknownHeterozygous:Heterozygous pups with a maternal, but not paternal, deletion of the miRNA cluster display partially penetrant neonatal lethality with defects in the maintenance of energy homeostasis. |
References |
|
Homozygous fertile | not known |
Homozygous viable | not known |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Animals used for archiving | heterozygous C57BL/6J males |
Disease and phenotype information
MGI phenotypes (allele matching)
MGI phenotypes (gene matching)
- hypoglycemia / MGI
- abnormal suckling behavior / MGI
- postnatal growth retardation / MGI
- abnormal glucose homeostasis / MGI
- decreased circulating ketone body level / MGI
- abnormal insulin secretion / MGI
- decreased circulating glucose level / MGI
- increased liver glycogen level / MGI
- mortality/aging / MGI
- postnatal lethality, incomplete penetrance / MGI
- perinatal lethality, incomplete penetrance / MGI
Literature references
- The miR-379/miR-410 cluster at the imprinted Dlk1-Dio3 domain controls neonatal metabolic adaptation.;Labialle Stéphane, Marty Virginie, Bortolin-Cavaillé Marie-Line, Hoareau-Osman Magali, Pradère Jean-Philippe, Valet Philippe, Martin Pascal G P, Cavaillé Jérôme, ;2014;The EMBO journal;33;2216-30; 25124681
- Deletion of the miR-379/miR-410 gene cluster at the imprinted Dlk1-Dio3 locus enhances anxiety-related behaviour.;Marty Virginie, Labialle Stéphane, Bortolin-Cavaillé Marie-Line, Ferreira De Medeiros Gabriela, Moisan Marie-Pierre, Florian Cédrick, Cavaillé Jérôme, ;2016;Human molecular genetics;25;728-39; 26744330
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