B6.129-Mirc36tm1.1Jcav/Orl

Status

Available to order

EMMA IDEM:10967
International strain nameB6.129-Mirc36tm1.1Jcav/Orl
Alternative nameKO-miR-379/miR-410
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolMirc36tm1.1Jcav
Gene/Transgene symbolMirc36

Information from provider

ProviderCavaille Jerome
Provider affiliationLBME-CNRS-UMR5099
Genetic informationA Cre-loxP-mediated deletion that removes the maternally-expressed miR-379/miR-410 gene cluster at the imprinted DlK1-Dio3 domain.
Phenotypic informationHomozygous:
Unknown

Heterozygous:
Heterozygous pups with a maternal, but not paternal, deletion of the miRNA cluster display partially penetrant neonatal lethality with defects in the maintenance of energy homeostasis.
References
  • The miR-379/miR-410 cluster at the imprinted Dlk1-Dio3 domain controls neonatal metabolic adaptation.;Labialle Stéphane, Marty Virginie, Bortolin-Cavaillé Marie-Line, Hoareau-Osman Magali, Pradère Jean-Philippe, Valet Philippe, Martin Pascal G P, Cavaillé Jérôme, ;2014;The EMBO journal;33;2216-30; 25124681
  • Deletion of the miR-379/miR-410 gene cluster at the imprinted Dlk1-Dio3 locus enhances anxiety-related behaviour.;Marty Virginie, Labialle Stéphane, Bortolin-Cavaillé Marie-Line, Ferreira De Medeiros Gabriela, Moisan Marie-Pierre, Florian Cédrick, Cavaillé Jérôme, ;2016;Human molecular genetics;25;728-39; 26744330
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France
Animals used for archivingheterozygous C57BL/6J

Disease and phenotype information

MGI phenotypes (allele matching)
  • hypoglycemia / MGI
  • abnormal suckling behavior / MGI
  • postnatal growth retardation / MGI
  • abnormal glucose homeostasis / MGI
  • decreased circulating ketone body level / MGI
  • abnormal insulin secretion / MGI
  • decreased circulating glucose level / MGI
  • increased liver glycogen level / MGI
  • mortality/aging / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • perinatal lethality, incomplete penetrance / MGI
MGI phenotypes (gene matching)
  • hypoglycemia / MGI
  • abnormal suckling behavior / MGI
  • postnatal growth retardation / MGI
  • abnormal glucose homeostasis / MGI
  • decreased circulating ketone body level / MGI
  • abnormal insulin secretion / MGI
  • decreased circulating glucose level / MGI
  • increased liver glycogen level / MGI
  • mortality/aging / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • perinatal lethality, incomplete penetrance / MGI

Literature references

  • The miR-379/miR-410 cluster at the imprinted Dlk1-Dio3 domain controls neonatal metabolic adaptation.;Labialle Stéphane, Marty Virginie, Bortolin-Cavaillé Marie-Line, Hoareau-Osman Magali, Pradère Jean-Philippe, Valet Philippe, Martin Pascal G P, Cavaillé Jérôme, ;2014;The EMBO journal;33;2216-30; 25124681
  • Deletion of the miR-379/miR-410 gene cluster at the imprinted Dlk1-Dio3 locus enhances anxiety-related behaviour.;Marty Virginie, Labialle Stéphane, Bortolin-Cavaillé Marie-Line, Ferreira De Medeiros Gabriela, Moisan Marie-Pierre, Florian Cédrick, Cavaillé Jérôme, ;2016;Human molecular genetics;25;728-39; 26744330

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.


Search
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).