B6;C3-Tg(GFAP-SRC)2Aag/Cnrm

Status	Available to order
EMMA ID	EM:00109
International strain name	B6;C3-Tg(GFAP-SRC)2Aag/Cnrm
Alternative name	GFAPv-src-Tg
Strain type	Transgenic Strains
Allele/Transgene symbol	Tg(GFAP-SRC)2Aag
Gene/Transgene symbol	Tg(GFAP-SRC)2Aag

Information from provider

Provider	Adriano Aguzzi
Provider affiliation	Univ.Hosp.Zurich/Inst.Neuropathology
Genetic information	Astrocyte-specific expression of v-SRC kinase. Insertion of v-SRC into exon 1 of a 17kb expression construct, consisting of the entire exon/intron structure of the mouse GFAP gene plus SV40 late gene splicing and polyadenylation signal in exon 1 (copy number 32).
Breeding history	Crossed to C57BL/6 then intercrossed
References	Development and malignant progression of astrocytomas in GFAP-v-src transgenic mice.;Weissenberger J, Steinbach J P, Malin G, Spada S, Rülicke T, Aguzzi A, ;1997;Oncogene;14;2005-13; 9160879

Information from EMMA

Archiving centre	CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

MGI allele-associated human disease models

astrocytoma / DOID:3069

Literature references

Development and malignant progression of astrocytomas in GFAP-v-src transgenic mice.;Weissenberger J, Steinbach J P, Malin G, Spada S, Rülicke T, Aguzzi A, ;1997;Oncogene;14;2005-13; 9160879

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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