C57BL/6N-Kctd13^em2(IMPC)Ics/Ics

Status	Available to order
EMMA ID	EM:10884
International strain name	C57BL/6N-Kctd13^em2(IMPC)Ics/Ics
Alternative name
Strain type	Endonuclease-mediated
Allele/Transgene symbol	Kctd13^em2(IMPC)Ics
Gene/Transgene symbol	Kctd13

Information from provider

Provider	ICS, Institut Clinique de la Souris
Provider affiliation	ICS, Institut Clinique de la Souris
Genetic information	This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	Targeting the RHOA pathway improves learning and memory in adult Kctd13 and 16p11.2 deletion mouse models.;Martin Lorenzo Sandra, Nalesso Valérie, Chevalier Claire, Birling Marie-Christine, Herault Yann, ;2021;Molecular autism;12;1; 33436060 Dissecting the autism-associated 16p11.2 locus identifies multiple drivers in neuroanatomical phenotypes and unveils a male-specific role for the major vault protein.;Kretz Perrine F, Wagner Christel, Mikhaleva Anna, Montillot Charlotte, Hugel Sylvain, Morella Ilaria, Kannan Meghna, Fischer Marie-Christine, Milhau Maxence, Yalcin Ipek, Brambilla Riccardo, Selloum Mohammed, Herault Yann, Reymond Alexandre, Collins Stephan C, Yalcin Binnaz, ;2023;Genome biology;24;261; 37968726

Information from EMMA

Archiving centre	ICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France

Literature references

Targeting the RHOA pathway improves learning and memory in adult Kctd13 and 16p11.2 deletion mouse models.;Martin Lorenzo Sandra, Nalesso Valérie, Chevalier Claire, Birling Marie-Christine, Herault Yann, ;2021;Molecular autism;12;1; 33436060
Dissecting the autism-associated 16p11.2 locus identifies multiple drivers in neuroanatomical phenotypes and unveils a male-specific role for the major vault protein.;Kretz Perrine F, Wagner Christel, Mikhaleva Anna, Montillot Charlotte, Hugel Sylvain, Morella Ilaria, Kannan Meghna, Fischer Marie-Christine, Milhau Maxence, Yalcin Ipek, Brambilla Riccardo, Selloum Mohammed, Herault Yann, Reymond Alexandre, Collins Stephan C, Yalcin Binnaz, ;2023;Genome biology;24;261; 37968726

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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C57BL/6N-Kctd13em2(IMPC)Ics/Ics