C57BL/6N-Atm1Brd Id2tm2a(EUCOMM)Wtsi/WtsiOulu

Status

Available to order

EMMA IDEM:10867
Citation informationRRID:IMSR_EM:10867 

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International strain nameC57BL/6N-Atm1Brd Id2tm2a(EUCOMM)Wtsi/WtsiOulu
Alternative nameEPD0977_1_G04
Strain typeTargeted Mutant Strains
Allele/Transgene symbolId2tm2a(EUCOMM)Wtsi
Gene/Transgene symbolId2
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0977_1_G04. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreUniversity of Oulu, Oulu, Finland

Disease and phenotype information

IMPC phenotypes (gene matching)
  • increased blood urea nitrogen level / IMPC
  • increased circulating creatinine level / IMPC
MGI phenotypes (gene matching)
  • hydronephrosis / MGI
  • small inner medullary pyramid / MGI
  • abnormal branching of the mammary ductal tree / MGI
  • abnormal olfactory bulb morphology / MGI
  • weight loss / MGI
  • decreased body size / MGI
  • hypoactivity / MGI
  • postnatal growth retardation / MGI
  • decreased white adipose tissue amount / MGI
  • abnormal immune system physiology / MGI
  • abnormal lactation / MGI
  • abnormal olfaction / MGI
  • no abnormal phenotype detected / MGI
  • decreased lymph node number / MGI
  • abnormal oropharyngeal lymphoid tissue morphology / MGI
  • small olfactory bulb / MGI
  • absent Peyer's patches / MGI
  • no phenotypic analysis / MGI
  • loss of dopaminergic neurons / MGI
  • premature neuronal precursor differentiation / MGI
  • ischuria / MGI
  • nervous system phenotype / MGI
  • decreased lean body mass / MGI
  • abnormal rostral migratory stream morphology / MGI
  • abnormal neuronal precursor proliferation / MGI
  • abnormal cell differentiation / MGI
  • adipose tissue phenotype / MGI
  • behavior/neurological phenotype / MGI
  • abnormal mammary gland growth during pregnancy / MGI
  • absent lymph nodes / MGI
  • decreased NK T cell number / MGI
  • decreased NK cell number / MGI
  • absent NK cells / MGI
  • decreased CD8-positive, alpha-beta T cell number / MGI
  • abnormal common lymphocyte progenitor cell morphology / MGI
  • decreased survivor rate / MGI
  • decreased inguinal fat pad weight / MGI
  • decreased interscapular fat pad weight / MGI
  • distended ileum / MGI
  • postnatal lethality, complete penetrance / MGI
  • neonatal lethality, incomplete penetrance / MGI
  • abnormal ureteropelvic junction morphology / MGI
  • ureteropelvic junction stenosis / MGI
  • distended jejunum / MGI
  • arrhythmic circadian behavior persistence / MGI
  • abnormal circadian behavior phase / MGI

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Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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