C57BL/6NTac-Trex1tm1(KOMP)Wtsi/WtsiOulu

Status

Available to order

EMMA IDEM:10857
International strain nameC57BL/6NTac-Trex1tm1(KOMP)Wtsi/WtsiOulu
Alternative nameEPD0296_3_C07
Strain type
Allele/Transgene symbolTrex1tm1(KOMP)Wtsi
Gene/Transgene symbolTrex1
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from KOMP ES clone EPD0296_3_C07. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreUniversity of Oulu, Oulu, Finland

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (allele matching)
IMPC phenotypes (gene matching)
MGI phenotypes (gene matching)
  • abnormal heart morphology / MGI
  • enlarged heart / MGI
  • abnormal myocardial fiber morphology / MGI
  • folliculitis / MGI
  • lymphoid hyperplasia / MGI
  • enlarged spleen / MGI
  • enlarged lymph nodes / MGI
  • thymus cortex hypoplasia / MGI
  • atelectasis / MGI
  • dermatitis / MGI
  • skin lesions / MGI
  • hepatic necrosis / MGI
  • abnormal T cell activation / MGI
  • increased inflammatory response / MGI
  • heart inflammation / MGI
  • abnormal atrial thrombosis / MGI
  • myocarditis / MGI
  • kidney inflammation / MGI
  • lung inflammation / MGI
  • vasculitis / MGI
  • pancreas inflammation / MGI
  • salivary gland inflammation / MGI
  • stomach inflammation / MGI
  • decreased litter size / MGI
  • premature death / MGI
  • abnormal kidney morphology / MGI
  • abnormal spleen marginal zone morphology / MGI
  • increased IgG level / MGI
  • abnormal immune system organ morphology / MGI
  • glomerulonephritis / MGI
  • dilated heart atrium / MGI
  • cardiac fibrosis / MGI
  • increased autoantibody level / MGI
  • renal necrosis / MGI
  • myositis / MGI
  • myocardial fiber degeneration / MGI
  • increased anti-double stranded DNA antibody level / MGI
  • increased anti-nuclear antigen antibody level / MGI
  • increased susceptibility to systemic lupus erythematosus / MGI
  • skin inflammation / MGI
  • increased spleen weight / MGI
  • increased regulatory T cell number / MGI
  • increased B cell number / MGI
  • cardiomyopathy / MGI
  • increased susceptibility to autoimmune disorder / MGI
  • immune system phenotype / MGI
  • congestive heart failure / MGI
  • dilated heart ventricle / MGI
  • increased CD4-positive, alpha beta T cell number / MGI
  • increased plasma cell number / MGI
  • abnormal spleen B cell follicle morphology / MGI
  • abnormal interferon secretion / MGI
  • lacrimal gland inflammation / MGI
  • increased splenocyte number / MGI
  • liver vascular congestion / MGI
  • tubulointerstitial nephritis / MGI
  • renal glomerular immunoglobulin deposits / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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