STOCK Tg(Sox2-cre/ERT2)1Skn/Cnrm
| Status | Available to order |
| EMMA ID | EM:10853 |
| Citation information | RRID:IMSR_EM:10853 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | STOCK Tg(Sox2-cre/ERT2)1Skn/Cnrm |
| Alternative name | Sox2CreERT2 |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Sox2-cre/ERT2)1Skn |
| Gene/Transgene symbol | Tg(Sox2-cre/ERT2)1Skn |
Information from provider
| Provider | Silvia Nicolis |
| Provider affiliation | Department of Biotechnology and Biosciences, University of Milano-Bicocca |
| Genetic information | The telencephalic promoter-enhancer of the Sox2 gene (Zappone et al., Development 2000, 127:2367-2382) is cloned upstream to the CreERT2 gene, encoding the tamoxifen-inducible Cre recombinase (see Favaro et al., Nature Neuroscience 2009,12:1248-1256). |
| Phenotypic information | Homozygous:No phenotypeHeterozygous:No phenotype |
| Breeding history | The transgenic line was generated by pronuclear injection of C57BL/6 x DBA oocytes, and the transgenic line was maintained by breeding of heterozygous carriers to non-carrier cousins. |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Literature references
- Hippocampal development and neural stem cell maintenance require Sox2-dependent regulation of Shh.;Favaro Rebecca, Valotta Menella, Ferri Anna L M, Latorre Elisa, Mariani Jessica, Giachino Claudio, Lancini Cesare, Tosetti Valentina, Ottolenghi Sergio, Taylor Verdon, Nicolis Silvia K, ;2009;Nature neuroscience;12;1248-56; 19734891