C57BL/6N-Atm1Brd Kcne1tm1a(EUCOMM)Hmgu/Ics

Status

Available to order

EMMA IDEM:10850
International strain nameC57BL/6N-Atm1Brd Kcne1tm1a(EUCOMM)Hmgu/Ics
Alternative nameHEPD0659_5_A11
Strain typeTargeted Mutant Strains
Allele/Transgene symbolKcne1tm1a(EUCOMM)Hmgu
Gene/Transgene symbolKcne1
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider ICS, Institut Clinique de la Souris
Provider affiliationICS, Institut Clinique de la Souris
Genetic informationThis mouse line originates from EUCOMM ES clone HEPD0659_5_A11. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France
Animals used for archivingheterozygous C57BL/6N

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • decreased startle reflex / IMPC
  • hyperactivity / IMPC
  • decreased locomotor activity / IMPC
  • abnormal startle reflex / IMPC
  • increased lean body mass / IMPC
  • decreased prepulse inhibition / IMPC
  • decreased bone mineral content / IMPC
  • increased circulating alanine transaminase level / IMPC
  • abnormal behavior / IMPC
  • decreased thigmotaxis / IMPC
  • head bobbing / IMPC
  • decreased anxiety-related response / IMPC
  • abnormal locomotor behavior / IMPC
  • abnormal cued conditioning behavior / IMPC
  • increased monocyte cell number / IMPC
  • increased blood urea nitrogen level / IMPC
  • abnormal motor capabilities/coordination/movement / IMPC
  • increased circulating alkaline phosphatase level / IMPC
  • decreased vertical activity / IMPC
  • abnormal auditory brainstem response / IMPC
  • decreased bone mineral density / IMPC
  • impaired righting response / IMPC
  • trunk curl / IMPC
  • increased neutrophil cell number / IMPC
  • decreased lymphocyte cell number / IMPC
  • decreased total body fat amount / IMPC
  • tremors / IMPC
  • abnormal gait / IMPC
  • increased mean corpuscular volume / IMPC
MGI phenotypes (gene matching)
  • abnormal inner ear morphology / MGI
  • abnormal cochlea morphology / MGI
  • abnormal inner ear vestibule morphology / MGI
  • organ of Corti degeneration / MGI
  • absent organ of Corti / MGI
  • abnormal stria vascularis morphology / MGI
  • ataxia / MGI
  • circling / MGI
  • bidirectional circling / MGI
  • unidirectional circling / MGI
  • hyperactivity / MGI
  • impaired coordination / MGI
  • stereotypic behavior / MGI
  • head bobbing / MGI
  • dehydration / MGI
  • decreased startle reflex / MGI
  • abnormal posture / MGI
  • impaired swimming / MGI
  • impaired righting response / MGI
  • impaired limb coordination / MGI
  • abnormal digestive system physiology / MGI
  • abnormal reflex / MGI
  • deafness / MGI
  • abnormal semicircular canal morphology / MGI
  • increased hematocrit / MGI
  • increased circulating aldosterone level / MGI
  • cochlear ganglion degeneration / MGI
  • abnormal otolith morphology / MGI
  • increased circulating chloride level / MGI
  • abnormal tectorial membrane morphology / MGI
  • abnormal scala media morphology / MGI
  • prolonged QT interval / MGI
  • abnormal cochlear sensory epithelium morphology / MGI
  • abnormal circulating renin level / MGI
  • abnormal feces composition / MGI
  • abnormal ear physiology / MGI
  • hypokalemia / MGI
  • abnormal myocardial fiber physiology / MGI
  • abnormal crista ampullaris morphology / MGI
  • vestibular hair cell degeneration / MGI
  • vestibular saccular macula degeneration / MGI
  • utricular macular degeneration / MGI
  • cochlear hair cell degeneration / MGI
  • absent cochlear inner hair cells / MGI
  • absent cochlear outer hair cells / MGI
  • absent cochlear hair cells / MGI
  • abnormal crista ampullaris neuroepithelium morphology / MGI
  • absent outer hair cell stereocilia / MGI
  • abnormal auditory brainstem response / MGI
  • abnormal vestibular system physiology / MGI
  • abnormal vestibular dark cell morphology / MGI
  • vestibular dark cell degeneration / MGI
  • absent linear vestibular evoked potential / MGI
  • absent vestibuloocular reflex / MGI
  • head tilt / MGI
  • head tossing / MGI
  • increased circulating sodium level / MGI
  • collapsed Reissner membrane / MGI
  • absent pinna reflex / MGI
  • absent startle reflex / MGI
  • small scala media / MGI
  • increased blood osmolality / MGI
  • increased or absent threshold for auditory brainstem response / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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