C57BL/6N-Atm1Brd Cog6tm1a(EUCOMM)Wtsi/WtsiFlmg

Status

Available to order

EMMA IDEM:10819
International strain nameC57BL/6N-Atm1Brd Cog6tm1a(EUCOMM)Wtsi/WtsiFlmg
Alternative nameEPD0609_4_H05
Strain typeTargeted Mutant Strains
Allele/Transgene symbolCog6tm1a(EUCOMM)Wtsi
Gene/Transgene symbolCog6
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0609_4_H05. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreB.S.R.C. Alexander Fleming, Vari, Greece

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (allele matching)
  • decreased hematocrit / IMPC
  • increased leukocyte cell number / IMPC
  • increased monocyte cell number / IMPC
  • increased granulocyte number / IMPC
  • abnormal cornea morphology / IMPC
  • abnormal coat/hair pigmentation / IMPC
  • increased mean platelet volume / IMPC
  • decreased hemoglobin content / IMPC
  • decreased erythrocyte cell number / IMPC
  • increased circulating alkaline phosphatase level / IMPC
  • vertebral transformation / IMPC
  • abnormal bone structure / IMPC
  • increased anti-nuclear antigen antibody level / IMPC
  • increased eosinophil cell number / IMPC
  • decreased T cell number / IMPC
  • increased circulating aspartate transaminase level / IMPC
  • increased circulating bilirubin level / IMPC
  • decreased mean corpuscular hemoglobin / IMPC
  • increased circulating total protein level / IMPC
  • decreased mean corpuscular hemoglobin concentration / IMPC
  • decreased NK T cell number / IMPC
  • decreased NK cell number / IMPC
  • increased CD4-positive, alpha-beta T cell number / IMPC
  • decreased CD8-positive, alpha-beta T cell number / IMPC
  • increased plasma cell number / IMPC
  • increased follicular B cell number / IMPC
  • decreased marginal zone B cell number / IMPC
  • increased B-2 B cell number / IMPC
  • increased gamma-delta T cell number / IMPC
  • increased circulating amylase level / IMPC
  • decreased transitional stage T2 B cell number / IMPC
  • increased red blood cell distribution width / IMPC
  • decreased bone mineral content / IMPC
  • increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number / IMPC
  • increased CD4-positive, alpha-beta memory T cell number / IMPC
  • decreased effector memory CD8-positive, alpha-beta T cell number / IMPC
  • decreased alpha-beta T cell number / IMPC
  • increased KLRG1-positive NK cell number / IMPC
  • increased Ly6C high monocyte number / IMPC
  • increased KLRG1+ CD8 alpha-beta T cell number / IMPC
  • increased KLRG1+ CD4 alpha-beta T cell number / IMPC
  • decreased memory-marker gamma-delta T cell number / IMPC
  • increased memory-marker gamma-delta T cell number / IMPC
  • increased CD5-positive gamma-delta T cell number / IMPC
  • decreased memory-marker NK cell number / IMPC
  • increased memory-marker NK cell number / IMPC
  • increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number / IMPC
  • increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number / IMPC
  • decreased CD8-positive, naive alpha-beta T cell number / IMPC
  • increased CD4-negative NK T cell number / IMPC
  • decreased memory-marker CD4-negative NK T cell number / IMPC
  • decreased CD4-positive NK T cell number / IMPC
  • decreased memory-marker CD4-positive NK T cell number / IMPC
  • decreased Ly6C-positive immature NK cell number / IMPC
  • decreased Ly6C-positive mature NK cell number / IMPC
  • decreased T-helper cell number / IMPC
  • increased effector memory T-helper cell number / IMPC
  • increased KLRG1-positive T-helper cell number / IMPC
IMPC phenotypes (gene matching)
  • decreased alpha-beta T cell number / IMPC
  • decreased NK T cell number / IMPC
  • increased memory-marker gamma-delta T cell number / IMPC
  • increased CD4-positive, alpha-beta memory T cell number / IMPC
  • decreased memory-marker CD4-positive NK T cell number / IMPC
  • decreased CD8-positive, alpha-beta T cell number / IMPC
  • decreased T cell number / IMPC
  • increased B-2 B cell number / IMPC
  • increased anti-nuclear antigen antibody level / IMPC
  • increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number / IMPC
  • decreased bone mineral content / IMPC
  • increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number / IMPC
  • increased KLRG1-positive T-helper cell number / IMPC
  • increased gamma-delta T cell number / IMPC
  • decreased NK cell number / IMPC
  • increased CD5-positive gamma-delta T cell number / IMPC
  • decreased memory-marker CD4-negative NK T cell number / IMPC
  • increased circulating aspartate transaminase level / IMPC
  • increased KLRG1+ CD8 alpha-beta T cell number / IMPC
  • decreased effector memory CD8-positive, alpha-beta T cell number / IMPC
  • increased Ly6C high monocyte number / IMPC
  • decreased memory-marker NK cell number / IMPC
  • increased KLRG1-positive NK cell number / IMPC
  • increased leukocyte cell number / IMPC
  • decreased mean corpuscular hemoglobin concentration / IMPC
  • abnormal coat/hair pigmentation / IMPC
  • increased monocyte cell number / IMPC
  • decreased erythrocyte cell number / IMPC
  • decreased CD8-positive, naive alpha-beta T cell number / IMPC
  • increased follicular B cell number / IMPC
  • abnormal cornea morphology / IMPC
  • decreased hematocrit / IMPC
  • increased circulating alkaline phosphatase level / IMPC
  • increased granulocyte number / IMPC
  • increased plasma cell number / IMPC
  • decreased Ly6C-positive immature NK cell number / IMPC
  • increased effector memory T-helper cell number / IMPC
  • increased CD4-positive, alpha-beta T cell number / IMPC
  • increased KLRG1+ CD4 alpha-beta T cell number / IMPC
  • increased CD4-negative NK T cell number / IMPC
  • decreased T-helper cell number / IMPC
  • abnormal bone structure / IMPC
  • increased red blood cell distribution width / IMPC
  • decreased Ly6C-positive mature NK cell number / IMPC
  • decreased transitional stage T2 B cell number / IMPC
  • increased eosinophil cell number / IMPC
  • increased circulating amylase level / IMPC
  • decreased hemoglobin content / IMPC
  • decreased CD4-positive NK T cell number / IMPC
  • increased circulating total protein level / IMPC
  • decreased mean corpuscular hemoglobin / IMPC
  • decreased memory-marker gamma-delta T cell number / IMPC
  • increased mean platelet volume / IMPC
  • increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number / IMPC
  • vertebral transformation / IMPC
  • decreased marginal zone B cell number / IMPC
  • increased memory-marker NK cell number / IMPC
  • increased circulating bilirubin level / IMPC
MGI phenotypes (allele matching)
  • intracerebral hemorrhage / MGI
  • fusion of vertebral arches / MGI
  • abnormal inferior vena cava morphology / MGI
  • abnormal liver vasculature morphology / MGI
  • muscular ventricular septal defect / MGI
  • abnormal inferior vena cava valve morphology / MGI
  • dual inferior vena cava / MGI
  • thin hypoglossal nerve / MGI
  • abnormal vitelline vein connection / MGI
  • abnormal ductus venosus valve morphology / MGI
  • abnormal coronary sinus connection / MGI
  • abnormal vertebral artery topology / MGI
MGI phenotypes (gene matching)
  • intracerebral hemorrhage / MGI
  • no abnormal phenotype detected / MGI
  • fusion of vertebral arches / MGI
  • abnormal inferior vena cava morphology / MGI
  • abnormal liver vasculature morphology / MGI
  • muscular ventricular septal defect / MGI
  • abnormal inferior vena cava valve morphology / MGI
  • dual inferior vena cava / MGI
  • thin hypoglossal nerve / MGI
  • abnormal vitelline vein connection / MGI
  • abnormal ductus venosus valve morphology / MGI
  • abnormal coronary sinus connection / MGI
  • abnormal vertebral artery topology / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.


Search
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).