B6;129-Rev3ltm1Crey/Cnbc

Status

Available to order

EMMA IDEM:10791
Citation informationRRID:IMSR_EM:10791 

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International strain nameB6;129-Rev3ltm1Crey/Cnbc
Alternative nameB6-129-Rev3L(catlytic mutant)
Strain typeTargeted Mutant Strains : Knock-in
Allele/Transgene symbolRev3ltm1Crey
Gene/Transgene symbolRev3l

Information from provider

ProviderClaude-Agnes Reynaud
Provider affiliationINSERM U1151/CNRS UMR 8253, Institut Necker-Enfants Malades
Genetic informationKnock-in mutations of the catalytic site of Rev3l DNA polymerase.
Phenotypic informationHomozygous:
No obvious phenotype.

Heterozygous:
No obvious phenotype
References
  • A single aspartate mutation in the conserved catalytic site of Rev3L generates a hypomorphic phenotype in vivo and in vitro.;Fritzen Rémi, Delbos Frédéric, De Smet Annie, Palancade Benoît, Canman Christine E, Aoufouchi Said, Weill Jean-Claude, Reynaud Claude-Agnès, Storck Sébastien, ;2016;DNA repair;46;37-46; 27481099
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreCNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain
Animals used for archivinghomozygous C57BL/6;129 males

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • increased mean corpuscular hemoglobin concentration / IMPC
  • abnormal retina morphology / IMPC
  • hyperactivity / IMPC
  • decreased mean corpuscular volume / IMPC
  • cataract / IMPC
  • decreased circulating creatinine level / IMPC
  • preweaning lethality, complete penetrance / IMPC
  • decreased blood urea nitrogen level / IMPC
MGI phenotypes (gene matching)
  • incomplete somite formation / MGI
  • abnormal somite shape / MGI
  • decreased embryo size / MGI
  • abnormal visceral yolk sac morphology / MGI
  • embryonic growth arrest / MGI
  • pericardial edema / MGI
  • abnormal embryonic tissue morphology / MGI
  • abnormal vitelline vasculature morphology / MGI
  • abnormal craniofacial development / MGI
  • embryonic growth retardation / MGI
  • spontaneous chromosome breakage / MGI
  • delayed embryo turning / MGI
  • abnormal embryonic neuroepithelium morphology / MGI
  • abnormal somatic hypermutation frequency / MGI
  • immune system phenotype / MGI
  • abnormal mesenchyme morphology / MGI
  • embryonic lethality between implantation and somite formation, complete penetrance / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI
  • neural tube degeneration / MGI
  • increased cell death / MGI
  • increased embryonic tissue cell apoptosis / MGI

Literature references

  • A single aspartate mutation in the conserved catalytic site of Rev3L generates a hypomorphic phenotype in vivo and in vitro.;Fritzen Rémi, Delbos Frédéric, De Smet Annie, Palancade Benoît, Canman Christine E, Aoufouchi Said, Weill Jean-Claude, Reynaud Claude-Agnès, Storck Sébastien, ;2016;DNA repair;46;37-46; 27481099

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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