C57BL/6NTac-Cps1em1(IMPC)H/H

Status

Available to order

EMMA IDEM:10778
International strain nameC57BL/6NTac-Cps1em1(IMPC)H/H
Alternative name
Strain typeEndonuclease-mediated
Allele/Transgene symbolCps1em1(IMPC)H
Gene/Transgene symbolCps1

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom
Animals used for archivingheterozygous C57BL/6NTac
Breeding at archiving centreMaintained on a C7BL/6NTac background

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

    • Classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency, salt wasting form / Orphanet_315306
    • Classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency, simple virilizing form / Orphanet_315311
    • Carbamoyl-phosphate synthetase 1 deficiency / Orphanet_147
IMPC phenotypes (allele matching)
  • decreased neutrophil cell number / IMPC
  • increased circulating HDL cholesterol level / IMPC
  • increased lymphocyte cell number / IMPC
  • increased circulating cholesterol level / IMPC
  • thrombocytosis / IMPC
  • decreased circulating potassium level / IMPC
  • increased grip strength / IMPC
  • preweaning lethality, complete penetrance / IMPC
IMPC phenotypes (gene matching)
  • thrombocytosis / IMPC
  • increased circulating HDL cholesterol level / IMPC
  • preweaning lethality, complete penetrance / IMPC
  • decreased circulating potassium level / IMPC
  • increased circulating cholesterol level / IMPC
  • decreased neutrophil cell number / IMPC
  • increased lymphocyte cell number / IMPC
  • increased grip strength / IMPC

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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