C57BL/6NTac-Abcc5em1(IMPC)H/H

Status

Available to order

EMMA IDEM:10761
International strain nameC57BL/6NTac-Abcc5em1(IMPC)H/H
Alternative name
Strain typeEndonuclease-mediated
Allele/Transgene symbolAbcc5em1(IMPC)H
Gene/Transgene symbolAbcc5

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
References
  • Abcc5 Knockout Mice Have Lower Fat Mass and Increased Levels of Circulating GLP-1.;Cyranka Malgorzata, Veprik Anna, McKay Eleanor J, van Loon Nienke, Thijsse Amber, Cotter Luke, Hare Nisha, Saibudeen Affan, Lingam Swathi, Pires Elisabete, Larraufie Pierre, Reimann Frank, Gribble Fiona, Stewart Michelle, Bentley Elizabeth, Lear Pamela, McCullagh James, Cantley James, Cox Roger D, de Wet Heidi, ;2019;Obesity (Silver Spring, Md.);27;1292-1304; 31338999

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom
Animals used for archivingheterozygous C57BL/6NTac
Breeding at archiving centreMaintained on a C57BL/6NTac background

Disease and phenotype information

IMPC phenotypes (allele matching)
  • decreased circulating calcium level / IMPC
  • decreased leukocyte cell number / IMPC
  • increased startle reflex / IMPC
  • limb grasping / IMPC
  • decreased eosinophil cell number / IMPC
  • decreased lymphocyte cell number / IMPC
  • impaired glucose tolerance / IMPC
  • decreased circulating glucose level / IMPC
  • increased blood urea nitrogen level / IMPC
IMPC phenotypes (gene matching)
  • decreased circulating calcium level / IMPC
  • increased blood urea nitrogen level / IMPC
  • decreased eosinophil cell number / IMPC
  • decreased circulating glucose level / IMPC
  • limb grasping / IMPC
  • impaired glucose tolerance / IMPC
  • increased startle reflex / IMPC
  • decreased lymphocyte cell number / IMPC
  • decreased leukocyte cell number / IMPC

Literature references

  • Abcc5 Knockout Mice Have Lower Fat Mass and Increased Levels of Circulating GLP-1.;Cyranka Malgorzata, Veprik Anna, McKay Eleanor J, van Loon Nienke, Thijsse Amber, Cotter Luke, Hare Nisha, Saibudeen Affan, Lingam Swathi, Pires Elisabete, Larraufie Pierre, Reimann Frank, Gribble Fiona, Stewart Michelle, Bentley Elizabeth, Lear Pamela, McCullagh James, Cantley James, Cox Roger D, de Wet Heidi, ;2019;Obesity (Silver Spring, Md.);27;1292-1304; 31338999

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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