C57BL/6N-Il15^{tm1c(EUCOMM)Hmgu}/H

Status	Available to order
EMMA ID	EM:10738
International strain name	C57BL/6N-Il15^{tm1c(EUCOMM)Hmgu}/H
Alternative name	HEPD0629_7_C06
Strain type	Targeted Mutant Strains : Targeted Conditional
Allele/Transgene symbol	Il15^{tm1c(EUCOMM)Hmgu}
Gene/Transgene symbol	Il15
Disclaimer	Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA: We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Provider	MRC, Medical Research Council
Provider affiliation	Mary Lyon Centre at MRC Harwell
Genetic information	This line originates from EUCOMM ES clone HEPD0629_7_C06, after breeding with a Flp recombinase deleter line to convert the original targeted allele tm1a (knock-out first allele) into a conditional allele tm1c. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	None available

Archiving centre	Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom
Animals used for archiving	wild-type C57BL/6NTacUSA, heterozygous C57BL/6NTacUSA

IMPC phenotypes (gene matching)

MGI phenotypes (gene matching)

abnormal immune system morphology / MGI
decreased body weight / MGI
abnormal immune system physiology / MGI
altered susceptibility to infection / MGI
decreased IgG level / MGI
decreased IgM level / MGI
small lymph nodes / MGI
abnormal dendritic cell physiology / MGI
decreased immunoglobulin level / MGI
abnormal lymphocyte morphology / MGI
abnormal cytokine secretion / MGI
abnormal decidualization / MGI
abnormal uterine artery morphology / MGI
abnormal CD8-positive, alpha-beta T cell physiology / MGI
decreased regulatory T cell number / MGI
increased susceptibility to parasitic infection / MGI
impaired natural killer cell mediated cytotoxicity / MGI
immune system phenotype / MGI
decreased susceptibility to type IV hypersensitivity reaction / MGI
abnormal NK T cell number / MGI
decreased NK T cell number / MGI
decreased NK cell number / MGI
absent uterine NK cells / MGI
decreased memory T cell number / MGI
decreased CD8-positive, alpha-beta T cell number / MGI
abnormal CD8-positive, alpha-beta T cell differentiation / MGI
decreased dendritic cell number / MGI
decreased CD8-positive, gamma-delta intraepithelial T cell number / MGI
decreased interferon-gamma secretion / MGI
abnormal interleukin secretion / MGI
decreased interleukin-12 secretion / MGI
abnormal thymus cell ratio / MGI
decreased susceptibility to bacterial infection induced morbidity/mortality / MGI
increased susceptibility to viral infection induced morbidity/mortality / MGI

Information from provider