IMPC phenotypes (allele matching)
C57BL/6N-Pink1tm1b(EUCOMM)Wtsi/H
| Status | Available to order |
| EMMA ID | EM:10737 |
| International strain name | C57BL/6N-Pink1tm1b(EUCOMM)Wtsi/H |
| Alternative name | EPD0787_2_G02 |
| Strain type | Targeted Mutant Strains |
| Allele/Transgene symbol | Pink1tm1b(EUCOMM)Wtsi |
| Gene/Transgene symbol | Pink1 |
| Disclaimer | Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
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Information from provider
| Provider | MRC, Medical Research Council |
| Provider affiliation | Mary Lyon Centre at MRC Harwell |
| Genetic information | This mouse line originates from EUCOMM ES clone EPD0787_2_G02. For further details on the construction of this clone see the page at the IMPC portal. The critical exon(s) were flanked by loxP sites, and subsequent cre expression excised this critical sequence resulting in a knockout reporter allele. Click here for more information on EUCOMM final vectors. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Young-onset Parkinson disease / Orphanet_2828
MGI phenotypes (gene matching)
- abnormal cerebral cortex morphology / MGI
- decreased body weight / MGI
- abnormal social investigation / MGI
- hypoactivity / MGI
- abnormal gait / MGI
- reduced long term potentiation / MGI
- reduced long term depression / MGI
- extended life span / MGI
- abnormal olfaction / MGI
- abnormal sensory capabilities/reflexes/nociception / MGI
- abnormal innervation / MGI
- abnormal nervous system electrophysiology / MGI
- no phenotypic analysis / MGI
- increased neuron apoptosis / MGI
- abnormal dopaminergic neuron morphology / MGI
- nervous system phenotype / MGI
- abnormal nervous system physiology / MGI
- oxidative stress / MGI
- abnormal neuron physiology / MGI
- abnormal lysosome morphology / MGI
- endocrine/exocrine gland phenotype / MGI
- cellular phenotype / MGI
- behavior/neurological phenotype / MGI
- abnormal cell physiology / MGI
- decreased dopamine level / MGI
- abnormal mitochondrion morphology / MGI
- abnormal mitochondrial physiology / MGI
- increased interleukin-1 beta secretion / MGI
- increased interleukin-10 secretion / MGI
- increased interleukin-12 secretion / MGI
- increased sensitivity to induced cell death / MGI
- abnormal olfactory bulb glomerular layer morphology / MGI
- abnormal cellular respiration / MGI
- abnormal respiratory electron transport chain / MGI
- abnormal mitochondrial ATP synthesis coupled electron transport / MGI