IMPC phenotypes (gene matching)
C57BL/6NTac-Atf4tm1(EGFP/Cre/ERT2)Wtsi/WtsiIeg
| Status | Available to order |
| EMMA ID | EM:10711 |
| International strain name | C57BL/6NTac-Atf4tm1(EGFP/Cre/ERT2)Wtsi/WtsiIeg |
| Alternative name | CEPD0073_2_E06 |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Atf4tm1(EGFP/Cre/ERT2)Wtsi |
| Gene/Transgene symbol | Atf4 |
Information from provider
| Provider | Wellcome Trust Sanger Institute |
| Provider affiliation | Wellcome Trust Sanger Institute |
| Genetic information | This mouse line originates from EUCOMM ES clone CEPD0073_2_E06. For further details on the construction of this clone see the page at the IMPC portal. Quality Control/Disclaimer: The structure of the targeted mutation is not fully verified. It is recommended that the recipient confirms the mutation structure by Southern blotting. The Cre expression pattern is expected to mirror that of the host gene, but this may not be fully described and/or may be modified in the targeted allele. Although characterisation of the Cre expression pattern is an objective of EUCOMMTools this is an ongoing process which may be incomplete. It is therefore recommended that the recipient verifies the Cre expression pattern. For the tm1(EGFP/Cre/ERT2) type allele, if the promoter-driven selection cassette is flanked with Rox sites, it may be removed using Dre recombinase. Please be aware that the strain description may be subject to change. For the most recent description please consult the information pages for the appropriate product details at the IMPC portal. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
Disease and phenotype information
MGI phenotypes (gene matching)
- decreased bone mineral density / MGI
- abnormal neurocranium morphology / MGI
- abnormal frontal bone morphology / MGI
- abnormal parietal bone morphology / MGI
- decreased hematocrit / MGI
- absent common myeloid progenitor cells / MGI
- decreased cell proliferation / MGI
- ruffled hair / MGI
- delayed hair appearance / MGI
- pale liver / MGI
- decreased hepatocyte number / MGI
- decreased body length / MGI
- decreased body weight / MGI
- decreased body size / MGI
- microphthalmia / MGI
- abnormal iris morphology / MGI
- anemia / MGI
- impaired hematopoiesis / MGI
- postnatal growth retardation / MGI
- reduced male fertility / MGI
- male infertility / MGI
- female infertility / MGI
- abnormal pancreas morphology / MGI
- increased circulating insulin level / MGI
- abnormal vas deferens morphology / MGI
- abnormal lens fiber morphology / MGI
- increased insulin sensitivity / MGI
- abnormal bone mineralization / MGI
- increased insulin secretion / MGI
- aphakia / MGI
- abnormal gluconeogenesis / MGI
- decreased fetal size / MGI
- abnormal ciliary body morphology / MGI
- eyelids fail to open / MGI
- improved glucose tolerance / MGI
- abnormal clavicle morphology / MGI
- exocrine pancreas hypoplasia / MGI
- decreased circulating glucose level / MGI
- abnormal bone ossification / MGI
- abnormal osteoblast differentiation / MGI
- increased lens epithelium apoptosis / MGI
- decreased total fat pad weight / MGI
- increased pancreatic beta cell mass / MGI
- abnormal pancreatic acinus morphology / MGI
- abnormal pancreatic acinar cell morphology / MGI
- abnormal pancreatic acinar cell zymogen granule morphology / MGI
- abnormal bone trabecula morphology / MGI
- postnatal lethality, incomplete penetrance / MGI
- perinatal lethality, incomplete penetrance / MGI
- increased pancreatic beta cell proliferation / MGI
- large fontanelles / MGI