IMPC phenotypes (gene matching)
C57BL/6NTac-Lef1tm1(EGFP/cre/ERT2)Wtsi/WtsiIeg
| Status | Available to order |
| EMMA ID | EM:10707 |
| International strain name | C57BL/6NTac-Lef1tm1(EGFP/cre/ERT2)Wtsi/WtsiIeg |
| Alternative name | CEPD0064_5_G08 |
| Strain type | |
| Allele/Transgene symbol | Lef1tm1(EGFP/cre/ERT2)Wtsi |
| Gene/Transgene symbol | Lef1 |
Information from provider
| Provider | Wellcome Trust Sanger Institute |
| Provider affiliation | Wellcome Trust Sanger Institute |
| Genetic information | This mouse line originates from EUCOMM ES clone CEPD0064_5_G08. For further details on the construction of this clone see the page at the IMPC portal. Quality Control/Disclaimer: The structure of the targeted mutation is not fully verified. It is recommended that the recipient confirms the mutation structure by Southern blotting. The Cre expression pattern is expected to mirror that of the host gene, but this may not be fully described and/or may be modified in the targeted allele. Although characterisation of the Cre expression pattern is an objective of EUCOMMTools this is an ongoing process which may be incomplete. It is therefore recommended that the recipient verifies the Cre expression pattern. For the tm1(EGFP/Cre/ERT2) type allele, if the promoter-driven selection cassette is flanked with Rox sites, it may be removed using Dre recombinase. Please be aware that the strain description may be subject to change. For the most recent description please consult the information pages for the appropriate product details at the IMPC portal. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
Disease and phenotype information
MGI phenotypes (gene matching)
- absent alveolar process / MGI
- arrest of tooth development / MGI
- absent incisors / MGI
- abnormal vascular regression / MGI
- abnormal hair follicle morphology / MGI
- decreased hair follicle number / MGI
- underdeveloped hair follicles / MGI
- absent hair follicle melanin granules / MGI
- alopecia / MGI
- pointed snout / MGI
- absent mammary gland / MGI
- abnormal hippocampus development / MGI
- absent hippocampus / MGI
- absent dentate gyrus / MGI
- absent barrels in primary somatosensory cortex / MGI
- absent mesencephalic trigeminal nucleus / MGI
- thin skin / MGI
- decreased body size / MGI
- absent vibrissae / MGI
- persistence of hyaloid vascular system / MGI
- abnormal brain morphology / MGI
- abnormal retinal vasculature morphology / MGI
- abnormal hair follicle development / MGI
- absent molars / MGI
- absent upper incisors / MGI
- absent lower incisors / MGI
- immune system phenotype / MGI
- abnormal hippocampus region morphology / MGI
- absent subcutaneous adipose tissue / MGI
- absent endometrial glands / MGI
- postnatal lethality, complete penetrance / MGI
- abnormal endometrial gland development / MGI
- abnormal mammary gland bud morphology / MGI
- absent teeth / MGI