C57BL/6NTac-Mbptm2(EGFP/cre/ERT2)Wtsi/WtsiIeg

Status

Available to order

EMMA IDEM:10705
International strain nameC57BL/6NTac-Mbptm2(EGFP/cre/ERT2)Wtsi/WtsiIeg
Alternative nameCEPD0093_2_E04
Strain type
Allele/Transgene symbolMbptm2(EGFP/cre/ERT2)Wtsi
Gene/Transgene symbolMbp

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from EUCOMM ES clone CEPD0093_2_E04. For further details on the construction of this clone see the page at the IMPC portal.
Quality Control/Disclaimer: The structure of the targeted mutation is not fully verified. It is recommended that the recipient confirms the mutation structure by Southern blotting. The Cre expression pattern is expected to mirror that of the host gene, but this may not be fully described and/or may be modified in the targeted allele. Although characterisation of the Cre expression pattern is an objective of EUCOMMTools this is an ongoing process which may be incomplete. It is therefore recommended that the recipient verifies the Cre expression pattern. For the tm2(EGFP/Cre/ERT2) type allele, if the promoter-driven selection cassette is flanked with Rox sites, it may be removed using Dre recombinase. Please be aware that the strain description may be subject to change. For the most recent description please consult the information pages for the appropriate product details at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreHelmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany

Disease and phenotype information

MGI phenotypes (gene matching)
  • tremors / MGI
  • hindlimb paralysis / MGI
  • abnormal corpus callosum morphology / MGI
  • abnormal myelination / MGI
  • demyelination / MGI
  • convulsive seizures / MGI
  • sporadic seizures / MGI
  • abnormal oligodendrocyte morphology / MGI
  • decreased body weight / MGI
  • abnormal maternal nurturing / MGI
  • ataxia / MGI
  • hypoactivity / MGI
  • impaired coordination / MGI
  • abnormal gait / MGI
  • abnormal spatial learning / MGI
  • decreased startle reflex / MGI
  • audiogenic seizures / MGI
  • limb grasping / MGI
  • premature death / MGI
  • abnormal CNS synaptic transmission / MGI
  • decreased susceptibility to viral infection / MGI
  • tonic seizures / MGI
  • abnormal neuron morphology / MGI
  • phenotypic reversion / MGI
  • reversion by mitotic recombination / MGI
  • absence seizures / MGI
  • abnormal myelin sheath morphology / MGI
  • decreased cholesterol level / MGI
  • abnormal axonal transport / MGI
  • increased susceptibility to experimental autoimmune encephalomyelitis / MGI
  • absent linear vestibular evoked potential / MGI
  • reduced linear vestibular evoked potential / MGI
  • abnormal behavior / MGI
  • increased T cell proliferation / MGI
  • immune system phenotype / MGI
  • reproductive system phenotype / MGI
  • vision/eye phenotype / MGI
  • abnormal action potential / MGI
  • abnormal brain white matter morphology / MGI
  • increased interferon-gamma secretion / MGI
  • increased interleukin-2 secretion / MGI
  • increased interleukin-4 secretion / MGI
  • decreased nerve conduction velocity / MGI
  • environmentally induced seizures / MGI
  • abnormal cerebellum white matter morphology / MGI
  • decreased brain cholesterol level / MGI
  • abnormal auditory brainstem response waveform shape / MGI
  • increased or absent threshold for auditory brainstem response / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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