C57BL/6-Tg(Kit*)7Mpel/Cnrm
Status | Available to order |
EMMA ID | EM:10644 |
International strain name | C57BL/6-Tg(Kit*)7Mpel/Cnrm |
Alternative name | c-KitTgD814Y/C57BL/6 |
Strain type | Transgenic Strains |
Allele/Transgene symbol | Tg(Kit*)7Mpel |
Gene/Transgene symbol | Tg(Kit*)7Mpel |
Information from provider
Provider | Manuela Pellegrini |
Provider affiliation | CNR-IBCN |
Genetic information | BAC RP23-309C11, containing c-Kit genome sequence was engineered substituting the G to T 2468 to generate c-Kit TgD814Y transgenic mice. |
Phenotypic information | Homozygous:Transgenic mice expressed c-Kit receptor 2.5-fold higher when compared to control mice and the receptor was constitutively activated in cerebellum, testis and heart. Mice did not show evident phenotypes in physiological conditions.Heterozygous:Transgenic mice expressed c-Kit receptor 2.5-fold higher when compared to control mice and the receptor was constitutively activated in cerebellum, testis and heart. Mice did not show evident phenotypes in physiological conditions. |
References |
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Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Literature references
- Activated c-Kit receptor in the heart promotes cardiac repair and regeneration after injury.;Di Siena S, Gimmelli R, Nori S L, Barbagallo F, Campolo F, Dolci S, Rossi P, Venneri M A, Giannetta E, Gianfrilli D, Feigenbaum L, Lenzi A, Naro F, Cianflone E, Mancuso T, Torella D, Isidori A M, Pellegrini M, ;2016;Cell death & disease;7;e2317; 27468693
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