C57BL/6-Tg(Kit*)7Mpel/Cnrm

Status	Available to order
EMMA ID	EM:10644
Citation information	RRID:IMSR_EM:10644 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	C57BL/6-Tg(Kit*)7Mpel/Cnrm
Alternative name	c-KitTgD814Y/C57BL/6
Strain type	Transgenic Strains
Allele/Transgene symbol	Tg(Kit*)7Mpel
Gene/Transgene symbol	Tg(Kit*)7Mpel

Information from provider

Provider	Manuela Pellegrini
Provider affiliation	CNR-IBCN
Genetic information	BAC RP23-309C11, containing c-Kit genome sequence was engineered substituting the G to T 2468 to generate c-Kit TgD814Y transgenic mice.
Phenotypic information	Homozygous: Transgenic mice expressed c-Kit receptor 2.5-fold higher when compared to control mice and the receptor was constitutively activated in cerebellum, testis and heart. Mice did not show evident phenotypes in physiological conditions. Heterozygous: Transgenic mice expressed c-Kit receptor 2.5-fold higher when compared to control mice and the receptor was constitutively activated in cerebellum, testis and heart. Mice did not show evident phenotypes in physiological conditions.
References	Activated c-Kit receptor in the heart promotes cardiac repair and regeneration after injury.;Di Siena S, Gimmelli R, Nori S L, Barbagallo F, Campolo F, Dolci S, Rossi P, Venneri M A, Giannetta E, Gianfrilli D, Feigenbaum L, Lenzi A, Naro F, Cianflone E, Mancuso T, Torella D, Isidori A M, Pellegrini M, ;2016;Cell death & disease;7;e2317; 27468693
Homozygous fertile	yes
Homozygous viable	yes
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Literature references

Activated c-Kit receptor in the heart promotes cardiac repair and regeneration after injury.;Di Siena S, Gimmelli R, Nori S L, Barbagallo F, Campolo F, Dolci S, Rossi P, Venneri M A, Giannetta E, Gianfrilli D, Feigenbaum L, Lenzi A, Naro F, Cianflone E, Mancuso T, Torella D, Isidori A M, Pellegrini M, ;2016;Cell death & disease;7;e2317; 27468693

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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