IMPC phenotypes (gene matching)
C57BL/6N-Lmnb1tm1c(EUCOMM)Wtsi/WtsiH
| Status | Available to order |
| EMMA ID | EM:10615 |
| International strain name | C57BL/6N-Lmnb1tm1c(EUCOMM)Wtsi/WtsiH |
| Alternative name | EPD0070_1_G07 |
| Strain type | Targeted Mutant Strains : Targeted Conditional |
| Allele/Transgene symbol | Lmnb1tm1c(EUCOMM)Wtsi |
| Gene/Transgene symbol | Lmnb1 |
| Disclaimer | Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
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Information from provider
| Provider | Wellcome Trust Sanger Institute |
| Provider affiliation | Wellcome Trust Sanger Institute |
| Genetic information | This line originates from EUCOMM ES clone EPD0070_1_G07, after breeding with a Flp recombinase deleter line to convert the original targeted allele tm1a (knock-out first allele) into a conditional allele tm1c. For further details on the construction of this clone see the page at the IMPC portal. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
| Animals used for archiving | heterozygous C57BL/6NTac |
| Breeding at archiving centre | This mutation was generated on a coisogenic C57BL/6NTac background |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Autosomal dominant primary microcephaly / Orphanet_2514
- Adult-onset autosomal dominant leukodystrophy / Orphanet_99027
MGI phenotypes (gene matching)
- delayed bone ossification / MGI
- scoliosis / MGI
- decreased circulating calcium level / MGI
- decreased cell proliferation / MGI
- microcephaly / MGI
- abnormal cranium morphology / MGI
- thin diaphragm muscle / MGI
- decreased brain size / MGI
- abnormal stratification in cerebral cortex / MGI
- abnormal lung morphology / MGI
- abnormal lung development / MGI
- absent pulmonary alveoli / MGI
- decreased body weight / MGI
- decreased embryo size / MGI
- respiratory failure / MGI
- abnormal pulmonary alveolus morphology / MGI
- abnormal neuron morphology / MGI
- decreased circulating alkaline phosphatase level / MGI
- abnormal thoracic vertebrae morphology / MGI
- abnormal cell nucleus morphology / MGI
- abnormal coronal suture morphology / MGI
- abnormal sagittal suture morphology / MGI
- decreased fetal size / MGI
- abnormal neuronal precursor proliferation / MGI
- abnormal cell differentiation / MGI
- increased mean corpuscular hemoglobin / MGI
- abnormal neuronal migration / MGI
- impaired lung alveolus development / MGI
- neonatal lethality, complete penetrance / MGI
- abnormal phrenic nerve innervation pattern to diaphragm / MGI
- decreased midbrain size / MGI
- flat head / MGI