C57BL/6-Atm1Brd Hnrnprtm1a(EUCOMM)Wtsi/Flmg

Status

Available to order

EMMA IDEM:10602
International strain nameC57BL/6-Atm1Brd Hnrnprtm1a(EUCOMM)Wtsi/Flmg
Alternative nameB6-Hnrnpr/Flmg
Strain typeTargeted Mutant Strains
Allele/Transgene symbolHnrnprtm1a(EUCOMM)Wtsi
Gene/Transgene symbolHnrnpr

Information from provider

ProviderMichael Sendtner
Provider affiliationInstitute for Clinical Neurobiology, University of Würzburg
Genetic informationThe L1L2_Bact_P cassette was inserted at position 136315880 of chromosome 4 upstream of the critical exon(s) (Build GRCm38). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 136316682. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other EUCOMM/KOMP alleles can be found here.
Phenotypic informationHomozygous:
Not characterized yet

Heterozygous:
Not characterized yet
References
  • Loss of full-length hnRNP R isoform impairs DNA damage response in motoneurons by inhibiting Yb1 recruitment to chromatin.;Ghanawi Hanaa, Hennlein Luisa, Zare Abdolhossein, Bader Jakob, Salehi Saeede, Hornburg Daniel, Ji Changhe, Sivadasan Rajeeve, Drepper Carsten, Meissner Felix, Mann Matthias, Jablonka Sibylle, Briese Michael, Sendtner Michael, ;2021;Nucleic acids research;49;12284-12305; 34850154
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requirednot known
Immunocompromisednot known

Information from EMMA

Archiving centreB.S.R.C. Alexander Fleming, Vari, Greece
Animals used for archivingheterozygous C57BL/6, wild-type C57BL/6
Stage of embryosMorula

Disease and phenotype information

IMPC phenotypes (gene matching)
  • decreased mean corpuscular hemoglobin concentration / IMPC
  • increased eosinophil cell number / IMPC
  • increased hematocrit / IMPC
  • increased mean corpuscular volume / IMPC
  • increased leukocyte cell number / IMPC
  • decreased red blood cell distribution width / IMPC
  • decreased exploration in new environment / IMPC
  • increased basophil cell number / IMPC
  • increased lymphocyte cell number / IMPC

Literature references

  • Loss of full-length hnRNP R isoform impairs DNA damage response in motoneurons by inhibiting Yb1 recruitment to chromatin.;Ghanawi Hanaa, Hennlein Luisa, Zare Abdolhossein, Bader Jakob, Salehi Saeede, Hornburg Daniel, Ji Changhe, Sivadasan Rajeeve, Drepper Carsten, Meissner Felix, Mann Matthias, Jablonka Sibylle, Briese Michael, Sendtner Michael, ;2021;Nucleic acids research;49;12284-12305; 34850154

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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