IMPC phenotypes (gene matching)
B6JRj.129P2(129S4)-Per2tm1.1Ual/Biat
| Status | Available to order |
| EMMA ID | EM:10599 |
| Citation information | RRID:IMSR_EM:10599 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6JRj.129P2(129S4)-Per2tm1.1Ual/Biat |
| Alternative name | B6;129P2Per2tm1Ual |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Per2tm1.1Ual |
| Gene/Transgene symbol | Per2 |
Information from provider
| Provider | Doron Shmerling |
| Provider affiliation | PolyGene AG |
| Additional owner | The owner is myself (Urs Albrecht, University of Fribourg). The strain was produced with PolyGene a company located near Zürich for pay. |
| Genetic information | 129P2/OlaHsd x C57BL/6 strain with floxed exon 6 of the Per2 gene. |
| Phenotypic information | Homozygous:No phenotype. Crossing with CMV-cre deleter results in total loss of Per2 in all tissues with a short free-running period and loss of food anticipatory activity. Circadian clock resetting in response to a nocturnal light pulse is also affected.Heterozygous:None of the above described phenotypes are observed. The animal is not distinguishable from wild-type. |
| Breeding history | Crossed over 10 generations, last 5 to C57BL/6JRj. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | University of Veterinary Medicine, Vienna, Austria |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Familial advanced sleep-phase syndrome / Orphanet_164736
MGI phenotypes (gene matching)
- salivary gland epithelial hyperplasia / MGI
- abnormal body weight / MGI
- increased body weight / MGI
- abnormal retina morphology / MGI
- pup cannibalization / MGI
- abnormal food preference / MGI
- abnormal sleep pattern / MGI
- abnormal blood vessel morphology / MGI
- increased mortality induced by gamma-irradiation / MGI
- reduced female fertility / MGI
- decreased litter size / MGI
- premature death / MGI
- no abnormal phenotype detected / MGI
- abnormal bone marrow cell morphology/development / MGI
- abnormal male preputial gland morphology / MGI
- abnormal retinal vasculature morphology / MGI
- no phenotypic analysis / MGI
- decreased cellular sensitivity to gamma-irradiation / MGI
- nervous system phenotype / MGI
- abnormal nervous system morphology / MGI
- increased incidence of tumors by ionizing radiation induction / MGI
- increased hematopoietic stem cell number / MGI
- abnormal brain wave pattern / MGI
- improved glucose tolerance / MGI
- behavior/neurological phenotype / MGI
- abnormal food intake / MGI
- abnormal maternal behavior / MGI
- abnormal basal metabolism / MGI
- early reproductive senescence / MGI
- prolonged estrous cycle / MGI
- absent estrous cycle / MGI
- abnormal pregnancy / MGI
- enhanced conditioned place preference behavior / MGI
- enhanced behavioral response to cocaine / MGI
- increased salivary gland tumor incidence / MGI
- abnormal hematopoietic stem cell physiology / MGI
- increased bone volume / MGI
- abnormal circadian temperature homeostasis / MGI
- decreased hematopoietic stem cell proliferation / MGI
- increased lymphoma incidence / MGI
- increased bone ossification / MGI
- abnormal circadian behavior / MGI
- shortened circadian behavior period / MGI
- arrhythmic circadian behavior persistence / MGI
- delayed circadian behavior phase / MGI
- abnormal locomotor circadian rhythm / MGI
- abnormal circadian sleep/wake cycle / MGI
Literature references
- Liver-derived ketone bodies are necessary for food anticipation.;Chavan Rohit, Feillet Céline, Costa Sara S Fonseca, Delorme James E, Okabe Takashi, Ripperger Jürgen A, Albrecht Urs, ;2016;Nature communications;7;10580; 26838474
- PER2 mediates CREB-dependent light induction of the clock gene Per1.;Brenna Andrea, Ripperger Jürgen A, Saro Gabriella, Glauser Dominique A, Yang Zhihong, Albrecht Urs, ;2021;Scientific reports;11;21766; 34741086
- Deletion of the clock gene Period2 (Per2) in glial cells alters mood-related behavior in mice.;Martini Tomaz, Ripperger Jürgen A, Stalin Jimmy, Kores Andrej, Stumpe Michael, Albrecht Urs, ;2021;Scientific reports;11;12242; 34112905
- Cyclin-dependent kinase 5 (CDK5) regulates the circadian clock.;Brenna Andrea, Olejniczak Iwona, Chavan Rohit, Ripperger Jürgen A, Langmesser Sonja, Cameroni Elisabetta, Hu Zehan, De Virgilio Claudio, Dengjel Jörn, Albrecht Urs, ;2019;eLife;8;1227; 31687929
- Bmal1 in the striatum influences alcohol intake in a sexually dimorphic manner.;de Zavalia Nuria, Schoettner Konrad, Goldsmith Jory A, Solis Pavel, Ferraro Sarah, Parent Gabrielle, Amir Shimon, ;2021;Communications biology;4;922080; 34702951
- Characterization of Affective Behaviors and Motor Functions in Mice With a Striatal-Specific Deletion of Bmal1 and Per2.;Schoettner Konrad, Alonso Mariana, Button Margo, Goldfarb Cassandra, Herrera Juliana, Quteishat Nour, Meyer Christiane, Bergdahl Andreas, Amir Shimon, ;2022;Frontiers in physiology;13;; 35755440