B6JRj.129P2(129S4)-Per2tm1.1Ual/Biat
| Status | Available to order |
| EMMA ID | EM:10599 |
| International strain name | B6JRj.129P2(129S4)-Per2tm1.1Ual/Biat |
| Alternative name | B6;129P2Per2tm1Ual |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Per2tm1.1Ual, |
| Gene/Transgene symbol | Per2 |
Information from provider
| Provider | Doron Shmerling |
| Provider affiliation | PolyGene AG |
| Additional owner | The owner is myself (Urs Albrecht, University of Fribourg). The strain was produced with PolyGene a company located near Zürich for pay. |
| Genetic information | 129P2/OlaHsd x C57BL/6 strain with floxed exon 6 of the Per2 gene. |
| Phenotypic information | Homozygous:No phenotype. Crossing with CMV-cre deleter results in total loss of Per2 in all tissues with a short free-running period and loss of food anticipatory activity. Circadian clock resetting in response to a nocturnal light pulse is also affected.Heterozygous:None of the above described phenotypes are observed. The animal is not distinguishable from wild-type. |
| Breeding history | Crossed over 10 generations, last 5 to C57BL/6JRj. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | University of Veterinary Medicine, Vienna, Austria |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Familial advanced sleep-phase syndrome / Orphanet_164736
Literature references
- Liver-derived ketone bodies are necessary for food anticipation.;Chavan Rohit, Feillet Céline, Costa Sara S Fonseca, Delorme James E, Okabe Takashi, Ripperger Jürgen A, Albrecht Urs, ;2016;Nature communications;7;10580; 26838474
- PER2 mediates CREB-dependent light induction of the clock gene Per1.;Brenna Andrea, Ripperger Jürgen A, Saro Gabriella, Glauser Dominique A, Yang Zhihong, Albrecht Urs, ;2021;Scientific reports;11;21766; 34741086
- Deletion of the clock gene Period2 (Per2) in glial cells alters mood-related behavior in mice.;Martini Tomaz, Ripperger Jürgen A, Stalin Jimmy, Kores Andrej, Stumpe Michael, Albrecht Urs, ;2021;Scientific reports;11;12242; 34112905
- Cyclin-dependent kinase 5 (CDK5) regulates the circadian clock.;Brenna Andrea, Olejniczak Iwona, Chavan Rohit, Ripperger Jürgen A, Langmesser Sonja, Cameroni Elisabetta, Hu Zehan, De Virgilio Claudio, Dengjel Jörn, Albrecht Urs, ;2019;eLife;8;1227; 31687929
- Bmal1 in the striatum influences alcohol intake in a sexually dimorphic manner.;de Zavalia Nuria, Schoettner Konrad, Goldsmith Jory A, Solis Pavel, Ferraro Sarah, Parent Gabrielle, Amir Shimon, ;2021;Communications biology;4;922080; 34702951
- Characterization of Affective Behaviors and Motor Functions in Mice With a Striatal-Specific Deletion of Bmal1 and Per2.;Schoettner Konrad, Alonso Mariana, Button Margo, Goldfarb Cassandra, Herrera Juliana, Quteishat Nour, Meyer Christiane, Bergdahl Andreas, Amir Shimon, ;2022;Frontiers in physiology;13;; 35755440