IMPC phenotypes (allele matching)
C57BL/6N-Ngfrtm1b(EUCOMM)Wtsi/H
| Status | Available to order |
| EMMA ID | EM:10598 |
| International strain name | C57BL/6N-Ngfrtm1b(EUCOMM)Wtsi/H |
| Alternative name | EPD0059_4_D03 |
| Strain type | Targeted Mutant Strains |
| Allele/Transgene symbol | Ngfrtm1b(EUCOMM)Wtsi |
| Gene/Transgene symbol | Ngfr |
| Disclaimer | Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
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Information from provider
| Provider | MRC, Medical Research Council |
| Provider affiliation | Mary Lyon Centre at MRC Harwell |
| Genetic information | This mouse line originates from EUCOMM ES clone EPD0059_4_D03. For further details on the construction of this clone see the page at the IMPC portal. The critical exon(s) were flanked by loxP sites, and subsequent cre expression excised this critical sequence resulting in a knockout reporter allele. Click here for more information on EUCOMM final vectors. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
| Animals used for archiving | heterozygous C57BL/6NTac |
| Breeding at archiving centre | Crossed to C57BL/6NTac |
Disease and phenotype information
IMPC phenotypes (gene matching)
- preweaning lethality, incomplete penetrance / IMPC
- abnormal digit morphology / IMPC
- abnormal eye morphology / IMPC
- increased startle reflex / IMPC
- limb grasping / IMPC
- abnormal gait / IMPC
- decreased circulating triglyceride level / IMPC
- decreased thigmotaxis / IMPC
- abnormal retina morphology / IMPC
- increased circulating phosphate level / IMPC
- tremors / IMPC
- abnormal behavior / IMPC
- decreased circulating alkaline phosphatase level / IMPC
- decreased locomotor activity / IMPC
MGI phenotypes (gene matching)
- organ of Corti degeneration / MGI
- absent hair follicles / MGI
- abnormal mouth morphology / MGI
- ulcerated paws / MGI
- abnormal tongue epithelium morphology / MGI
- abnormal superior colliculus morphology / MGI
- decreased motor neuron number / MGI
- abnormal dorsal root ganglion morphology / MGI
- abnormal sensory neuron innervation pattern / MGI
- small L4 dorsal root ganglion / MGI
- abnormal L5 dorsal root ganglion morphology / MGI
- abnormal cholinergic neuron morphology / MGI
- abnormal innervation pattern to muscle / MGI
- abnormal trigeminal ganglion morphology / MGI
- decreased Schwann cell number / MGI
- decreased body size / MGI
- ataxia / MGI
- abnormal gait / MGI
- abnormal spatial learning / MGI
- abnormal posture / MGI
- limb grasping / MGI
- abnormal blood vessel morphology / MGI
- postnatal growth retardation / MGI
- hemorrhage / MGI
- abnormal sensory capabilities/reflexes/nociception / MGI
- abnormal tooth morphology / MGI
- abnormal muscle morphology / MGI
- no abnormal phenotype detected / MGI
- decreased airway responsiveness / MGI
- abnormal sciatic nerve morphology / MGI
- abnormal molar morphology / MGI
- cochlear ganglion degeneration / MGI
- abnormal neuron morphology / MGI
- abnormal axon guidance / MGI
- decreased myocardial infarction size / MGI
- extremity edema / MGI
- abnormal neuron apoptosis / MGI
- decreased neuron apoptosis / MGI
- abnormal axon extension / MGI
- abnormal molar crown morphology / MGI
- dilated dorsal aorta / MGI
- abnormal peripheral nervous system regeneration / MGI
- abnormal proprioceptive neuron morphology / MGI
- cochlear hair cell degeneration / MGI
- sensorineural hearing loss / MGI
- increased susceptibility to age-related hearing loss / MGI
- increased susceptibility to experimental autoimmune encephalomyelitis / MGI
- abnormal vascular wound healing / MGI
- abnormal eye physiology / MGI
- renal/urinary system phenotype / MGI
- increased retinal photoreceptor cell number / MGI
- abnormal circumvallate papillae morphology / MGI
- abnormal gustatory papillae taste bud morphology / MGI
- abnormal retinal ganglion cell morphology / MGI
- abnormal Kupffer cell morphology / MGI
- decreased muscle spindle number / MGI
- abnormal tumor necrosis factor level / MGI
- increased neuron number / MGI
- abnormal axon pruning / MGI
- abnormal neuron differentiation / MGI
- perinatal lethality, incomplete penetrance / MGI
- increased or absent threshold for auditory brainstem response / MGI