STOCK Tg(tetO-Pax4*,-DsRed)/Cnbc

Status

Available to order

EMMA IDEM:10596
International strain nameSTOCK Tg(tetO-Pax4*,-DsRed)/Cnbc
Alternative namePAX4 R129W
Strain typeTransgenic Strains
Allele/Transgene symbolTg(tetO-Pax4*,-DsRed)
Gene/Transgene symbolTg(tetO-Pax4*,-DsRed)

Information from provider

ProviderBenoit Gauthier
Provider affiliationStem Cells, Andalusian Center of Molecular Biology and Regenerative Medicine (CABIMER)
Genetic informationTransgenic mouse with the potential to express a mutated variant of the transcription factor PAX4, PAX4R129W, together with fluorescent protein DsRed ubiquitously, under the control of TRE-pCMV inducible promoter. This mouse line should be crossed with any suitable rtTA or tTA line for tissue specific expression according to expression pattern of the rtTA or the tTA additional transgene.
Phenotypic informationHomozygous:
No apparent differences in comparison with non-transgenic mouse. Good general health. Without anatomic malformations or physiological troubles. No troubles of behavior.

Heterozygous:
No apparent differences in comparison with non-transgenic mouse. Good general health. Without anatomic malformations or physiological troubles. No troubles of behavior.
References
  • In vivo conditional Pax4 overexpression in mature islet β-cells prevents stress-induced hyperglycemia in mice.;Hu He Kai Hui, Lorenzo Petra I, Brun Thierry, Jimenez Moreno Carmen M, Aeberhard Deborah, Vallejo Ortega Jorge, Cornu Marion, Thorel Fabrizio, Gjinovci Asllan, Thorens Bernard, Herrera Pedro L, Meda Paolo, Wollheim Claes B, Gauthier Benoit R, ;2011;Diabetes;60;1705-15; 21521872
  • PAX4 preserves endoplasmic reticulum integrity preventing beta cell degeneration in a mouse model of type 1 diabetes mellitus.;Mellado-Gil José Manuel, Jiménez-Moreno Carmen María, Martin-Montalvo Alejandro, Alvarez-Mercado Ana Isabel, Fuente-Martin Esther, Cobo-Vuilleumier Nadia, Lorenzo Petra Isabel, Bru-Tari Eva, Herrera-Gómez Irene de Gracia, López-Noriega Livia, Pérez-Florido Javier, Santoyo-López Javier, Spyrantis Andreas, Meda Paolo, Boehm Bernhard O, Quesada Ivan, Gauthier Benoit R, ;2016;Diabetologia;59;755-65; 26813254
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreCNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain
Animals used for archivinghomozygous C57BL/6J

Literature references

  • In vivo conditional Pax4 overexpression in mature islet β-cells prevents stress-induced hyperglycemia in mice.;Hu He Kai Hui, Lorenzo Petra I, Brun Thierry, Jimenez Moreno Carmen M, Aeberhard Deborah, Vallejo Ortega Jorge, Cornu Marion, Thorel Fabrizio, Gjinovci Asllan, Thorens Bernard, Herrera Pedro L, Meda Paolo, Wollheim Claes B, Gauthier Benoit R, ;2011;Diabetes;60;1705-15; 21521872
  • PAX4 preserves endoplasmic reticulum integrity preventing beta cell degeneration in a mouse model of type 1 diabetes mellitus.;Mellado-Gil José Manuel, Jiménez-Moreno Carmen María, Martin-Montalvo Alejandro, Alvarez-Mercado Ana Isabel, Fuente-Martin Esther, Cobo-Vuilleumier Nadia, Lorenzo Petra Isabel, Bru-Tari Eva, Herrera-Gómez Irene de Gracia, López-Noriega Livia, Pérez-Florido Javier, Santoyo-López Javier, Spyrantis Andreas, Meda Paolo, Boehm Bernhard O, Quesada Ivan, Gauthier Benoit R, ;2016;Diabetologia;59;755-65; 26813254

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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